摘要
应用抗人胃低分化腺癌细胞系MKN46-9的单克隆抗体MG7对112例手术切除的大肠癌标本进行免疫组化观察,阳性106例(94.64％),强阳性占阳性病例的96.23％;96例癌旁粘膜中弱阳性26例(27.08％);14例断端正常粘膜仅1例呈弱阳性。46例大肠腺瘤中管状腺瘤43例,14例阳性(32.56％),3例绒毛状腺瘤均阳性。结果表明,MG7的抗原在大肠癌组织中含量较丰富,并具有相对特异性,同时在癌旁粘膜及大肠腺瘤组织中也有不同程度的表达。
This paper reports the results of immunohistochemical localization in colorectal carcinoma and adenoma by anti-human gastric carcinoma monoclonal antibody MG7.One hundred and twelve cases of colorectal carcinoma, 96 cases of surround-ing mucosa, 46 cases of adenoma and 14 cases of normal colonic mucosa wereexamined. One hundred and six of 112 cases of colorectal carcinoma were positivelystained (94.64%) and strong staining could be observed in 102 of 106 cases(96.23%). One of 14 cases normal colonic mucosa was only weak positive. Seventeen of46 cases adenoma revealed positive staining which was often associated with dys-plasia.These results suggest that MG7-associated antigen in human colorectal car-cinoma is abundant and relative specific antigen.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1989年第2期77-79,共3页
Cancer Research on Prevention and Treatment
