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纤溶酶原激活物抑制剂-1与脑梗死相关性的研究进展 被引量：1

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摘要 纤溶酶原激活物抑制剂-1(PAI-1)是tPA和uPA的主要抑制剂。PAI-1受PAI-1 基因调控,并受多种因素的影响。PAI-1在纤溶系统中起重要作用,与脑梗死的发生、发展和恢复有着密切的关系。PAI-1抑制剂也许可以提供与抗血小板药或抗凝药不同机制的新的抗血栓药。
作者 刘洲 赵斌
机构地区 广东医学院附属医院神经内科
出处 《神经疾病与精神卫生》 2005年第3期224-227,共4页 Journal of Neuroscience and Mental Health
关键词 纤溶酶原激活物抑制剂-1 基因多态性 脑梗死
分类号 R743.33 [医药卫生—神经病学与精神病学]
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参考文献32

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同被引文献26

  • 1陈立云,王拥军,赵性泉.脑梗死后出血性转化的研究进展[J].中国卒中杂志,2006,1(12):904-906. 被引量：33
  • 2全冠民,袁涛,刘怀军.急性脑梗死出血性转化及MRI评估[J].国外医学（临床放射学分册）,2006,29(5):311-314. 被引量：21
  • 3雷惠新,汪效松,张旭,程琼,周秀珍.急性脑血管病患者血浆t-PA、PAI-1活性测定及意义[J].卒中与神经疾病,2007,14(2):73-75. 被引量：5
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  • 6Barr TL,Latour LL,Lee KY,et al.Blood brain barrier disruption in humans is independently associated with increased matrix metalloproteinase 9[J].Stroke,2010,41(3):e123-e128.
  • 7Machado LS,Sazonova I,Kozak A,et al.Minocycline and tissue plasminogen activator for stroke:Assessment of interaction potential[J].Stroke,2009,40(9):3 028-3 033.
  • 8Kelly MA,Shuaib A,Todd KG,et al.Matrix metalloproteinase activation and blood brain barrier breakdown following thrombolysis[J].Exp Neurol,2006,200(1):38-49.
  • 9Castellanos M,Sobrino T,Millan M,et al.Serum cellular fibronectin and matrix metalloproteinase 9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke:a multicenter confirmatory study[J].Stroke,2007,38(6):1 855-1 859.
  • 10Ning M,Furie KL,Koroshetz WJ,et al.Association between tPA therapy and raised early matrix metalloproteinase 9 in acute stroke[J].Neurology,2006,66(10):1 550-1 555.

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神经疾病与精神卫生
2005年 第3期

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