摘要
目的:观察肾上腺髓质素(adrenomdedullin,ADM)在糖尿病大鼠血、尿、肾组织中的浓度变化以及转化生长因子β1(transforming growthing factor beta-1,TGF-β1)与血小板源性生长因子B(platelet derived growth factor-b,PDGF-B)的变化,探讨ADM在糖尿病肾病(diabetic nephropathy,DN)形成过程中的作用。方法:将实验大鼠分成正常对照组、糖尿病组、氯沙坦组。检测各组8周的血尿肌酐、尿蛋白、ADM、TGF-β1与PDGF-B及肾脏肥大指标的变化。结果:糖尿病组、氯沙坦组中的大鼠血、尿、肾组织ADM均明显增加(P<0.05),尿中ADM浓度高于血浆。氯沙坦组高于糖尿病组,但无统计学差异。糖尿病组TGF-β1与PDGF-B表达显著升高(P<0.05),氯沙坦组低于糖尿病组,但无统计学差异。氯沙坦可降低尿白蛋白及阻遏早期肾小球肥大。结论:ADM与TGF-β1与血PDGF-B有相关关系,ADM与DN的发展关系密切,可能起代偿性保护作用。
Objective.To investigate the role of adrenomdedullin（ADM） in the diabetic nephropathy （DN） through observing the changes of ADM, transforming growthing factor beta - 1 （TGF- β1 ） and platelet derived growth factor- b （PDGF - B） in the blood, urine and kidneys of diabetic rats. Methods： Rats were randomly divided into control group, diabetic group and losartan group. After 8 weeks, changes of serum creatinine, urinary protein, ADM, TGF - β1, PDGF - B and the index of renal hypertrophy were detected in each group. Results;ADM in the blood, urine and renal tissue increased markedly in diabetic group and losartan group （P〈0.05）. The level of ADM in urine was significantly higher than that in plasma. ADM in losartan group increased higher compared with that of diabetic group, but with no statistical difference. Losartan can suppress urinary albumin and glornemlar hypertrophy in renal tissue. Conclusion：ADM may be closely related to compensative Protection of DN, while expression of TGF- β1 and PDGF - B is related to progression of DN.
出处
《中国中西医结合肾病杂志》
2005年第9期506-509,共4页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
辽宁省科委基金资助项目(No.99225003)
