2Chong, J. A. , Tapia-Ramirez, J. , Kim, S. , Toledo-Aral, J. J,Zheng,Y, Boutros,M. C, Altshuer,Y. M, Frohman,M. A, Kraner,S. D, and Mandel, G. REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons . Cell.1995 Mar 24;80(6) :949-57.
3Schoenherr C. J and Anderson D.J. The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes. Science. 1995 Mar 3;267(5202): 1360-3.
4Thiel G, Leichter. M. Transcriptional repression by the zinc finger protein REST is mediated by titratable nuclear factors. Eur J Neurosci. 1999 Jun; 11(6): 1937-46.
5Tapia-Ramirez J, Eggen B. J, etal . A singer zinc finger motif in the silencing factor REST represses the neural-specific type Ⅱ sodium channel promoter. Proc Nat1 Acad Sci NSA 1997 Feb 18;94(4):1177-82.
6Gerald Thiel , Michael lietz and Matthias Gramer. Biological Activity and Modular structure of RE-1-silencing Transcription Factor (REST) a repressor of neuronal Genes. J Bio chem.. 1998 Oct9; 273 (41): 26891-9.
7Immaneni, A, Lawinger, P, Zhao, Z., Lu, W., Rastelli, L,Morris, J. H. , and Majumder, S. REST-VP16 activates multiple neuronal differentiation genes in human NT2 cells. Nucleic Acids Res. 2000 Sep 1;28(17):3403-10.
8Lawinger, P. , Venugopal, R. , Guo, Z. S. , Immaneni, A. , Sengupta,D. , Lu,W. , Rastelli,L. ,Marin Diascarneiro,A. , Levin,V. , Fuller,G. N. , etal. The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells. Nat Med. 2000Jul;6(7):826-31. Erratum in: Nat Med 2000 Sep;6(9):1062.
10Gilli R, Pagano SF, Gritti A. , etal. Regulation of neuronal differentiation in human CNS stem cell progeny by leukem inhibitory factor. Dev Neurosci. 2000;22(1-2):86-95.
2[1]Kuhn HG, Winkler J, Kempermann G, et al. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J Neurosci, 1997,17:5820～5829
3[2]Drago J, Murphy M, Carroll SM, et al. FGF-mediated proliferation of CNS precursors depends on endogenous production of IGF-1. Proc NatlAcadSciUSA, 1991,88:2199～2203
4[3]Kilpatrick TJ, Bartlett PF. Cloning and growth of multipotential neural precursors: requirements for proliferation and differentiation. Neuron, 1993,10:255～265
5[4]Brickman YG, Ford MD, Gallagher JT, et al. Structural modification of fibroblast growth factor-binding heparin sulfate at a determinative stage of neural development. J Biol Chem, 1998,273:4350～4359
6[5]Craig CG, Tropepe V, Morshead CM, et al. In Vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain. J Neurosci, 1996,16:2649～2658
7[6]Tanapat P, Gould E. EGF stimulates proliferation of granule cell precursors in the dentate gyrus of adult rats. Soc Neurosci Abstr, 1997,23:317
8[7]Satoh M, Sugino H, Yoshida T. Activin promotes astrocytic differentiation of a multipotent neural stem cell line and an astrocyte progenitor cell line from murine central nervous system. Neurosci Lett, 2000,284:143～146
9[8]Lillien L, Raphael H. BMP and FGF regulate the development of EGF-responsive neural progenitor cells. Development,2000,127: 4993～5005
10[9]Nakashima K, Yanagisawa M, Arakawa H, et al. Synergistic signaling in fetal brain by STAT3-Smad 1 complex bridged by p300, Science, 1999,284:479～482
4Fang LIN,Junchao WU,Yan WANG,and Zhenghong QIN Department of Pharmacology,Laboratory of Aging and Nervous Diseases,Soochow University School of Medicine,Suzhou 215123,China.Huntingtin Cleavage Induced by Thrombin In Vitro[J].Acta Biochimica et Biophysica Sinica,2007,39(1):15-18.
4Mulligan P, Westbrook TF, Ottinger M, et al. CDYL bridges REST and histone methyhransferases for gene repression and sup- pression of cellular transformation [ J]. Mol Cell, 2008, 32 (5) : 718 -726.
5Schoenhen" C J, Paquette AJ, Anderson DJ. Identification of po- tential target genes for the neuron -restrictive silencer factor [ J ]. Proc Natl Acad Sci U S A, 1996, 93(18) : 9881 -9886.
6Malarkey EB, Parpura V. Mechanisms of glutamate release from astrocytes[J].Neurochem Int, 2008, 52 (1/2) : 142 - 154.
7Schorge S, Colquhoun D. Studies of NMDA receptor function and stoichio metrywith truncated and tandem subunits [ J ]. Neurosci, 2003, 23(4) : 1151 -1158.
8Salter MG, Fern R. NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury[ J]. Nature, 2005, 438(7071) : 1167 - 1171.
9Ye Z, Rothstein J, Sontheimer H. Compromised glutamate trans- port in human glioma cells: reduction mislocalization of sodium - dependent glutamate transporters and enhanced activity of cystine glutamate exchange [ J ]. Neurosci, 1999, 19 (24) : 10767 - 10777.
10Karad6ttir R, Cavelier P, Bergersen LH, et al. NMDA receptors are expressed in ollgodendrocytes and activated in ischaemia [ J ]. Nature, 2005, 438(7071 ) : 1162 - 1166.
