摘要
目的探讨正常状态下smea3A在成年猫脊髓,其受体neuropilin-1(NP-1)在背根节(DRG)的分布。方法选取成年雄猫5只,用免疫组织化学方法检测脊髓中sema3A,DRG中NP-1的分布。结果脊髓中sema3A的阳性反应物主要分布于腹角的绝大部分运动神经元的胞浆;背根节中NP-1阳性产物主要分布在部分中小神经元及少量大神经元的胞浆中。结论脊髓中的sema3A可能抑制了背根节神经元在脊髓中的错误出芽,从而保持了脊髓中正常突触联系的稳定性。
Objective To study the contribution of sema3A in spinal cord and Neuropilin- 1（NP-1） in dorsal root ganglion （DRG） of intact adult cats. Methods Five male cats were selected. The expression of sema3A and NP-1 were studied with immunohistochemical method. Results In spinal cord, sema3A was mainly distributed in most motor neurons in ventral horn; In DRG, NP-1 was distributed in some medium, small neurons and a few large neurons. All subcellular location of positive product was in cytoplasm. Conelusion It indicated that sema3A in spinal cord may involve in preventing aberrant sprouting of DRG neurons and stabilizing synaptic contacts.
出处
《四川解剖学杂志》
2005年第3期1-3,共3页
Sichuan Journal of Anatomy
