摘要
以L半胱氨酸、L-焦谷氨酸为起始原料,经三步合成了匹多莫德。在传统的合成方法基础上进行了一定的改进,即在第二步的酯化反应中采用了冰浴条件下向无水甲醇中滴加CH3COCl,得到甲醇的HCl溶液,在其未达到饱和状态时仍取得了比较好的酯化结果,提高了产率,适合工业化。
Pidotimod, ara immunomodulator was synthesized in a three-step process with L-cysteine and L-pyroglutamic acid as starting materials. In this method, acetyl chloride was added to absolute methanol drop wise at the ice-bath temperature and an unsaturated solution of hydrogen chloride in methanol was obtained in the second step. This method gives good yield and is well adapted to industrialization
出处
《化学世界》
CAS
CSCD
北大核心
2005年第9期555-557,共3页
Chemical World
