摘要
目的掌握1992-2000年我国部分地区初治培阳肺结核患者耐药性变化情况,评价防治对策和措施的有效性。方法采用临床流行病学方法,对全国11个省12家结核病医疗及防治单位进行回顾性调查,分析初治耐药种类及耐药率的动态变化。结果初始耐药率、耐1药率和耐多药率分别为34.4%、16.7%、17.7%,与第一次调查结果(46.0%、20.6%、25.4%)比,均有明显下降。第二次调查前后两个时段初始耐药率和耐1药率也有明显下降,分别为37.4%、22.2%和32.8%、13.6%,而耐多药率尤其是M DR率则为明显上升,分别为15.1%、19.1%和4.6%、5.9%。结论DOTS策略能有效控制敏感菌感染的结核病,而耐多药Tb特别是M DR-Tb比率上升问题必须引起高度重视,其预防和治疗应纳入NTP。
Objective To understand TB-positive patients＇ drug-resistance conditions in some parts of the areas in China in the years of 1992 and 2000 and to evaluate the effectiveness of treatment. Methods A retrospective study was conducted to analyze changes of TB drug-resistance in 12 tuberculosis treatment and prevention institutes of 11 provinces in China. using clinical disease-prevalence method. Results The ratios for first-time durg-resistance, one-drug resistance and multiple-drug resistance were 34.4% 16.7% and 17.7% respectively, which were lower than that in the first-time study （46.0% 20.6%, and 25.4% respectively）. The ratiors for drug-resistance and for one-drug resistance in the second-time period were 37. 40% and 22.2% which were lower than that in the first-time （32.80% and 13.6% respectively）. However, for the multiple-drug resistance, the ratios in the second-time （15. 1% and 19. 1% respectively） were higher that those in the first-time （4. 6% and 5. 9% respectively）. Conclusion DOTS can be used effectively in treating TB patients. It should be noted that multiple-drug TB resistance especially MDR-TB has been increased, which should be included in the study of the prevention and treatment of TB using NTP.
出处
《临床肺科杂志》
2005年第6期698-699,共2页
Journal of Clinical Pulmonary Medicine
