摘要
目的研究砷对雌性大鼠血清中雌二醇、卵泡刺激素及黄体生成素、泌乳素水平及卵巢、肾上腺病理改变的影响。方法雌性大鼠经砷染毒10周后用放射免疫法测定血清中激素水平;光镜观察子宫和肾上腺的病理改变。结果除了黄体生成素各染毒组与对照组比较有统计学意义外,其余各组均无统计学意义;但卵巢及肾上腺有不同程度的病理改变。结论砷对雌性大鼠的内分泌激素黄体生成素是一个敏感指标,且对生殖系统有直接的损害作用。
Objective Effects of arsenic on the levels of estradiol （E2 ）, follicle stimulating hormone （FSH）, luteinizing hormone （LH） and prolactin （PRL） in serum of female rats, as well as histopathological changes of ovary and adrenal gland were researched, Methods The hormone levels of female rats were determined by RIA exposing arsenic for 10 weeks, and histopathological examination of ovary and adrenal gland were performed with light microscope. Results In spite of LH, there was no levels of three hormones （ P 〉 0.05） , However, different extents of histopathological changes in ovary and adrenal gland were found, ConcIusion LH is a sensitive index on hormones of female rats, but it may directly damage the reproductive system.
出处
《卫生研究》
CAS
CSCD
北大核心
2005年第5期537-538,共2页
Journal of Hygiene Research
基金
国家自然科学基金重大项目(No.39560075)
关键词
砷
大鼠
激素
病理组织学
arsenic, rats, hormones, histopathology
