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锌和铜在阿尔茨海默病中的作用 被引量：2

The roles of zinc and copper in alzheimer's disease
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摘要 综述了锌和铜在阿尔茨海默病中的作用及阿尔茨海默病患者脑中氧化还原活性金属之间的相互作用与作用机理,提出阿尔茨海默病的螯合疗法前景乐观。 The interactions of the redox active metals and their mechanisms in Alzheimer＇s disease （AD） were reviewed and the paradoxical roles of zinc in AD were discussed. It was suggested that chelation therapy for AD looks promising.
作者 李谷才 汪勇先 尹端沚
机构地区 中国科学院上海应用物理研究所放射性药物研究中心
出处 《国外医学（医学地理分册）》 CAS 2005年第3期109-112,117,共5页 Foreign Medical Sciences：Section of Medgeography
基金 国家自然科学基金资助项目(30371634)
关键词 阿尔茨海默病 锌 铜 Β-淀粉样蛋白 氧化应激 Alzheimer＇s disease zinc copper amyloid-β oxidative stress
分类号 Q581 [生物学—生物化学] R745.1 [医药卫生—神经病学与精神病学]
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参考文献18

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同被引文献41

  • 1杨频,李妙鱼.老年性痴呆的病因及其治疗药物的研究进展[J].山西大学学报（自然科学版）,2004,27(4):427-431. 被引量：12
  • 2建方方,仝玉萍,肖海连,汪庆祥,焦奎.Structure and Thermal Properties of Transition Metal Imidazole Chloride[J].Chinese Journal of Structural Chemistry,2004,23(9):979-984. 被引量：4
  • 3焦勇,韩大雄,杨频.铜离子(II)抑制Aβ多肽聚集机理的分子模拟[J].中国科学（B辑）,2005,35(4):303-311. 被引量：6
  • 4张志刚,马旭艳.铜锌等过渡金属离子与Aβ肽作用研究进展[J].山西大学学报（自然科学版）,2007,30(1):83-87. 被引量：3
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  • 6CAMPS P,EL ACHAB R,MORRAL J,et al.New Tacrine-Huperzine A Hybrids (Huprines):Highly Potent Tight-binding Acetylcholinesterase Inhibitors of Alzheimer's disease[J].J Med Chem,2000,43(24):4657-4666.
  • 7MIRANDA S OPAZO C,LARRONDO L F,et al.The role of Oxidative Stress in the Toxicity Induced by Amyloid Betapeptide in Alzheimer's disease[J].Prog Neurobiol,2000,62 (6):633-648.
  • 8DONG J,ATWOOD C S,ANDERSON V E,et al.Metal Binding and Oxidation of Amyloid-β within Isolated Senile Plaque Cores:Raman Microscopic Evidence[J].Biochemistry,2003,42 (10):2768-2773.
  • 9RAFFA D F,GOMEZ-BALDERAS R,et al.Ab Initio Model Studies of Copper Binding to Peptides Containing a HisHis Sequence:Relevance to the β-amyloid Peptide of Alzheimer's Disease[J].J Biol Inorg Chem,2005,10(8):887-902.
  • 10SYME C D,NADAL R C,et al.Copper Binding to the Amyloid-β (Aβ) Peptide Associated with Alzheimer's Disease:Folding,Coordination Geometry,pH Dependence,Stoichiometry,and Affinity of Aβ-(1-28):Insights from a Range of Complementary Spectroscopic Techniques[J].J Biol Chem,2004,279(18):18169-18177.

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二级引证文献3

国外医学（医学地理分册）
2005年 第3期

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