摘要
目的:探寻人巨细胞病毒感染与下腰痛存在的相关性,旨在进一步阐述下腰痛的可能病因。资料来源:应用计算机检索Medline 1992-01/2004-04的文章,检索词为“backpain,human cytomegalovirus,virus”,限定文章语言种类为Eng-lish。同时检索http://www.wanfangdata.com.cn/1998-01/2004-12的文章,检索词为“腰痛、人巨细胞病毒”,限定文章语言为中文。资料选择:纳入标准:①腰痛的病因学研究。②人巨细胞病毒感染与疼痛的相关研究。排除标准:①较陈旧的文献。②重复研究。③综述文献。资料提炼:共检索到181篇巨细胞病毒感梁与下腰痛相关文献,其中25篇符合标准,排除的其余文章系同一类的重复性研究、较陈旧的及综述文献。资料综合:①下腰痛简介:成年人中60%～80%有下腰痛史,但85%的下腰痛原因不明,临床上不能针对病因开展有效治疗,由此导致5%～10%的下腰痛转为慢性或致残,因而倍受国内外学者关注。Muneshige等指出病毒感染理论是揭开慢性局部疼痛之谜有吸引力的假说。②人巨细胞病毒简介:成年人群中人巨细胞病毒感染非常普遍,其抗体阳性率为40%～100%。人巨细胞病毒感染的临床类型分为亚临床感染/隐性感染和症状性感染。③人巨细胞病毒可能引起下腰痛的途径:有先天性感染、围生期感染和后天性感染;试验研究显示许多脊柱结构,包括韧带、平面关节、椎骨骨膜、椎骨周围的肌肉和筋膜、血管、纤维环和脊神经根病变可导致下腰痛。结论:人巨细胞病毒感染与下腰痛可能具有相关性,但其确切关系尚待进一步观察验证。
OBJECTIVE： To explore the correlation between human cytomegalovirus infection and low back pain, so as to further reveal the possible cause of low back pain, and provide clinical diagnosis and treatment of such a disease with some new evidence. DATA SOURCES： A computer-based online search of Medline database was undertaken to identify articles about human cytomegalovirus infection and low back pain published in English from January 1990 to April 2004 by using the keywords of “back pain, human cytomegalovirus, virus”. Chinese articles published between January 1998 anti December 2004 were searched on http：//www.wanfangdata.com.cn, the keywords were “back pain, human cytomegalovirus”： STUDY SELECTION： Inclusion criteria： ① study about the etiology of back pain;② study of the correlation between human cvtomegalovirus infection and back pain. Exclusion criteria： ①too old literatures;② repeated study;③summarized literatures. DATA EXTRACTION： Totally 181 related literatures were collected, among which 25 accorded with the inclusion criteria anti the excluded ones were either too old literatures or repeated studies. DATA SYNTHESIS： ① Introduction of low back pain： 60% to 80% of adults ever experienced or arc experiencing low back pain, but the causes of 85% of low back pain are uncertain, so that they cannot be effectively cured according to the concrete cause anti 5% to 10% of low back pain turns to chronic so as to make these patients with chronic low back pain disabled. For the reasons above, low back pain is commonly concerned domestically and abroad. Muneshige H et al. indicated that some theories of viral infection would be a promising hypothesis to explain the cause of low back pain.②Introduction of human cytomegalovirus： Among adults, the rates of the antibodies of human cytomegalovirus arc 40% to 100%, which indicates that human cytomegalovirus infection rate among adults is rather high. The clinical types of human cytomegalovirus intection are subclinical infection/inapparcnt infection anti symptomatic infection.③ The ways of low back pain caused by human cytomegalovirus infection are congenital infection, perinatal infection and acquired infection. It is indicated that many spinal structures, including ligament, plane joint, vertebral periosteum, muscle and fascia around vertebra, vessels, fibrous, and lesion of spinal nerve root, may lead to low back pain. CONCLUSION： Human cytomegalovirus infection may be related to low back pain. However, further studies are necessary.
出处
《中国临床康复》
CSCD
北大核心
2005年第30期197-198,共2页
Chinese Journal of Clinical Rehabilitation
基金
安徽省教育厅科学基金(2001KJ142
2004KJ230zc)~~
