2Sulavik MC, Houseweart C, Cramer C, et al. Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes[J]. Antimicrob Agents and Chemother, 2001, 45(4): 1126-1136.
3Touze T, Eswaran J, Bokma E, et al. Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system[J]. Mol Microbiol, 2004, 53(2) :697-706.
4Zgurskaya HI, Nikaido H. AcrA is a highly asymmetric protein capable of spanning the periplasm[J]. J MolBiol, 1999, 285 (1):409-420.
5Tikhonova EB, Wang QJ, Zgurskaya HI. Chimeric analysis of the multicomponent multidrug efflux transporters from gram-negative bacteria[J]. J Bacteriol, 2002, 184(23) :6499-6507.
6Zgurskaya HI, Nikaido H. Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli [ J ]. J Bacteriol,2000,182(15) :4264-4267.
7Elkins CA, Nikaido H. Chimeric analysis of AcrA function reveals the importance of its C-terminal domain in its interaction with the AcrB multidrug efflux pump [ J ]. J Bacteriol, 2003, 185 ( 18 ):5349-5356.
8Yu EW, McDermott G, Zgurskaya HI, et al. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump[J]. Science, 2003, 300(5621) :976-980.
9Elkins CA, Nikaido H. Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominately by two large periplasmic loops [ J ] . J Bacteriol, 2002,184 (23): 6490-6498.
10Murakami S, Nakashima R, Yamashita E, et al. Crystal structure of bacterial multidrug efflux transporter AcrB[J]. Nature, 2002,419(6907): 587-593.
9NIKAIDO H,ZGURSKAYA H I.AcrAB and related multidrug efflux pumps of Escherichia coli[J].Mol Microbiol,2001,3(2):215-218.
10ROSENBERG E Y,BERTENTHAL D,NILLES M L,et al.Bile salts and fatty acids induce the expression of Escherichia coli AcrAB muhidrug efflux pump through their interaction with Rob regulatory protein[J].Mol Microbiol,2003,48(6):1609-1619.
