摘要
用H5N2亚型禽流感疫苗,分别免疫SPF鸡、乌鸡、珍珠鸡、贵妃鸡、火鸡、鸭及鹅,免疫后采血测定其HI抗体,观察我国现有的H5N2亚型禽流感疫苗对特禽及水禽的免疫效力。结果,免疫后3周,SPF鸡、乌鸡、珍珠鸡、贵妃鸡、火鸡、鸭及鹅的平均HI抗体滴度分别为27.2、27.6、24.3、24.83、24.6、26.2及25.3,乌鸡两次免疫,其中一次HI抗体为29.65。试验证明,SPF鸡、特禽及水禽用H5N2亚型禽流感疫苗免疫后,均能产生一定水平的HI抗体,但不同种类的家禽所产生的HI抗体滴度存在较大差异,以SPF鸡及乌鸡所产生的HI抗体滴度最高,而珍珠鸡、贵妃鸡及火鸡所产生的HI抗体滴度较低,水禽对H5N2亚型禽流感疫苗可产生一定水平的HI抗体。
The inactivated vaccine against H5 subtype avian influenza was injected into SPF chicks, black-bone chickens, guinea fowls, Guifei chickens, turkeys, ducks and geese, respectively. Post-vaccination, blood samples of the fowls were collected for the detection of HI antibodies to H5 subtype avian influenza virus . At 21 days after vaccination, HI titers of SPF chickens, black-bone chicks, guinea fowls, Guifei chickens, turkeys, ducks and geese were 2^7.2, 2^7.6, 2^4.3, 2^4.83, 2^4.6, 2^6.2and 2^5.3 ,respectively. The higher HI titers in two trials with black-bone chickens was 2^9.65. The experiments indicated that HI antibodies could form in SPF chickens, special fowls and water fowls inoculated with H5N2 subtyupe avian influenza vaccine. There was a significant difference of HI titers in different kinds of fowls which were inoculated with the same vaccine. SPF chickens and black-bone chickens produced higher titers of HI antibodies. Guinea fowls, Guifei chickens and turkey produced lower titers of HI antibodies. Water fowls produced HI titers in medium level.
出处
《中国兽药杂志》
2005年第9期23-25,共3页
Chinese Journal of Veterinary Drug
关键词
H5N2亚型禽流感疫苗
特禽
水禽
免疫效力
H5N2 subtype avian influenza vaccine
special fowls
immunological efficacy
