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基质金属蛋白酶与急性脑血管病 被引量：1

Matrix Metalloproteinase and Acute Cerebrovascular Diseases
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摘要 基质金属蛋白酶(MMP)在脑血管基底膜的降解中起着重要作用,在病理条件下可导致血脑屏障受损,促进神经炎症反应的发生和发展。组织金属蛋白酶抑制剂(TIMP)是调节MMP活性的内源性抑制剂。MMP与TIMP平衡关系的失调与急性脑血管病的继发性脑损伤有关。人为地调控MMP与TIMP之间的平衡,有可能成为脑血管病的一条新的治疗途径。 Matrix metalloproteinases （MMPs） play an important part in degrading the basal lamina. They lead to disruption of the blood-brain barrier and contribute to the occurrence and development of neuroinflamrnatory response in pathological settings. Tissue inhibitor of metalloproteinases （TIMPs） are endogenous inhibitors that regulate the activity of the MMPs. The disturbrace of the equilibration between MMPs and TIMPs is associated with the secondary brain injury after acute cerebrovascular diseases. Artificially regulating the equilibration between MMPs and TIMPs may become a new approach in the treatment of cerebrovascular diseases.
作者 王珊 史福平 张国华
机构地区 河北医科大学第二医院神经内科
出处 《国外医学（脑血管疾病分册）》 2005年第7期541-544,共4页 Foreign Medical Sciences Cerebrovascular Diseases
关键词 基质金属蛋白酶 组织金属蛋白酶抑制剂 急性脑血管病 MMP活性 内源性抑制剂 继发性脑损伤 TIMP 血管基底膜 血脑屏障 病理条件 matrix metalloproteinases tissue inhibitor of metalloproteinase acute cerebrovascular diseases
分类号 R743.3 [医药卫生—神经病学与精神病学] R737.9 [医药卫生—肿瘤]
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参考文献23

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同被引文献29

  • 1张丽,张颖冬,李继民,张晓雷.基质金属蛋白酶-9/C1562T基因多态性与缺血性脑卒中的关系[J].临床神经病学杂志,2008,21(6):425-427. 被引量：7
  • 2吴丽娥,刘鸣,张月辉,赵晓玲,杨杰,谈颂,张世洪,吴波,谭燕,王清芳,王丽春,李伟.缺血性脑卒中TOAST病因分型和预后[J].中华神经科杂志,2004,37(4):292-295. 被引量：87
  • 3付锦,张雪梅.基质金属蛋白酶-9与脑梗死的关系[J].中国神经免疫学和神经病学杂志,2007,14(3):170-172. 被引量：6
  • 4万林,杜立峰,孙师元.基质金属蛋白酶2，9及其抑制剂3在脑梗死中的作用[J].中华急诊医学杂志,2007,16(6):611-614. 被引量：7
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二级引证文献3

国外医学（脑血管疾病分册）
2005年 第7期

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