摘要
Alzheimer病和血管性痴呆是老年人最常见的2种痴呆类型,两者的病理学存在显著关联。Alzheimer病的病理学特征主要是老年斑和神经原纤维缠结,与其相关的血管病理学表现还包括脑淀粉样血管病、微血管病变、脑白质损害、微梗死、腔隙性梗死和脑出血;相对而言,血管性痴呆的病理学变化具有不均一性,既包括传统的多发性脑梗死、微血管损害和缺血后脑病,也存在神经变性性病理学改变。
Alzheimer＇s disease （AD） and vascular dementia （VaD） are both the most common forms of dementia in elderly. There is significant association between them. The pathological characteristics of AD are mainly senile plaques and neurofibrillary tangles. Some vascular pathological changes are associated with AD, which include cerebral amyloid angiopathy, microvascular impairment, cerebral white matter lesion, cerebral microinfarct, lacunar infarct, and cerebral hemorrhage. Relatively, the pathological hallmarks of VaD show heterogeneity, which not only contain traditional multiple cerebral infarction, microvascular lesions and post-ischemic encephalopathy, but also involve neurodegenerative pathology.
出处
《国外医学（脑血管疾病分册）》
2005年第7期524-528,共5页
Foreign Medical Sciences Cerebrovascular Diseases
