摘要
提出了平行催化氢波测定萘普生的新方法.在KH2PO4-Na2HPO4(pH6.24±0.1)支持电解质中,萘普生产生一催化氢波,峰电位Ep=-1.36V(vs.SCE).加入K2SO8后,该催化氢波被催化,峰电流增加约20倍,峰电位基本不变,产生一较灵敏的平行催化氢波.其二阶导数峰峰电流ip″与萘普生浓度在1.0×10-7～3.2×10-5mol·L-1范围内呈线性关系(r=0.9992,n=8),检出限为5.0×10-8mol·L-1.该方法可用于药物制剂中萘普生含量的测定.
A polarographic method for the determination of naproxen is proposed. A catalytic hydrogen wave of naproxen at ca. - 1.36 （ vs. SCE） in 0.20 mol·L^-1 KH2PO4 - Na2HPO4 （ pH 6.24 ± 0.1 ） supporting electrolyte. When 1.0 × 10^-2 mol·L^-1 K2S2O8 is present, the current increases by 20 times, and the peak potentioal is unchanged, producing a more sensitive parallel catalytic hydrogen wave. The peak current of the parallel catalytic hydrogen wave is rectilinear to the naproxen concentration in the range 1.0 × 10^-7 - 3.2 × 10^-5 mol·L^-1 （ r = 0. 9992, n = 8）. The detection limit is 5.0 × 10^-8 mol·L^- 1. The proposed method can be applied to the determination of naproxen in pharmaceuticals without preliminary separation.
出处
《商丘师范学院学报》
CAS
2005年第5期110-113,共4页
Journal of Shangqiu Normal University
基金
河南省自然科学基金资助项目(0511020300)
关键词
萘普生
过二硫酸盐
催化氢波
平行催化氢波
单扫描示波极谱法
Naproxen
persulfate
catalytic hydrogen wave
parallel catalytic hydrogen wave
single sweep polarography
