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3-(4-羟基苄基)-8,9-二甲氧基-1,2,3,4-四氢苯并吡喃[3,4-c]吡啶-5-酮的合成 被引量：1

Synthesis of 3-(4-Hydrobenzyl)-8,9-dimethoxy-1,2,3,4-tetrahydrochromenopyridin-5-one
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摘要 以3,4-二甲氧基苯酚和哌啶-4-酮-3-甲酸甲酯盐酸盐为原料,通过分子间环加成反应和N-烷基化反应,合成了一种潜在的多巴胺D4受体配基3-(4-羟基苄基)-8,9-二甲氧基-1,2,3,4-四氢苯并吡喃[3,4-c]吡啶-5-酮,并用1HNMR、IR、ESI-MS对其进行了表征。 3- （4-Hydrobenzyl） -8,9-dimethoxy-1,2,3,4-tetrahydrochromeno [ 3,4-c ] pyridin-5-one was prepared as a potential dopamine D4 receptor ligand from 3,4-dimethoxyphenol and methyl 4-oxo-3- piperidinecarboxylate hydrochloride by two-step reactions and structures of the products were confirmed by IR, ^1HNMR and ESI -MS spectra.
作者 李谷才 尹端沚 夏姣云 汪勇先
机构地区 中国科学院上海应用物理研究所放射性药物研究中心
出处 《精细化工》 EI CAS CSCD 北大核心 2005年第9期694-695,共2页 Fine Chemicals
基金 国家自然科学基金资助项目(30371634) 中国科学院创新工程重大资助项目(KJCXI-SW-08)~~
关键词 苯并吡喃[3 4-c]吡啶-5-酬 多巴胺 chromeno [ 3,4-c ] pyridin-5-one dopamine
分类号 TQ224.7 [化学工程—有机化工]
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参考文献7

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同被引文献13

  • 1金国章.遐思:精神分裂症病因和药物治疗[J].中国处方药,2005(8):7-11. 被引量：5
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  • 9Linz S, M(iler J, Hiiner H, et aL Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases [ J ]. Bioorgan Med Chem, 2009,17 ( 13 ) : 4448 - 4458.
  • 10Lacivita E, De Giorgio P, Lee I T,et al. Design, synthesis, radiolabeling, and in vivo evaluation of carbon-11 labeled N-[ 2- [ 4-( 3-cyanopyridin-2-yl ) piperazin-l-yl [ ethyl ]-3- methoxybenzamide, a potential positron emission tomography tracer far the dopamine D4 receptors[ J]. J Med Chem,2010,53 (20) :7344 -7355.

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精细化工
2005年 第9期

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