摘要
目的探讨高敏感CRP(HSCRP)和前白蛋白(PA)测定在新生儿感染性疾病中的诊断价值。方法检测诊断明确的新生儿感染性疾病患儿治疗前后血中HSCRP和PA含量的变化。结果48例患儿中,治疗前血清HSCRP>3mg/L者45例(93.7%);PA<250mg/L者40例(83.3%)。在新生儿感染性疾病中,血清HSCRP显著升高,PA明显下降,以败血症、化脓性脑膜炎、肺炎变化最为突出,治疗前后比较差异有统计学意义(P<0.05);肠炎、脐炎、皮肤感染则无明显变化。随着感染的控制,临床症状体征逐步缓解,HSCRP逐渐下降,PA逐渐上升;全部病例治愈后,HSCRP<3mg/L,PA>250mg/L。结论动态观察测定血清HSCRP和PA含量的变化,可作为新生儿感染性疾病诊断、疗效和预后判断的重要指标之一。
Objective To explore diagnostical role of measurement of sera high-sensitivity C-reactive protein （HSCRP） and prealbumin （PA） in neonatal infectious diseases. Methods To test the changes of sera HSCRP and PA in neonatal infectious diseases by clinical diagnosed before and after treated. Results Of 48 infants, there were 45 cases （93.7%） whose sera HSCRP was more than 3mg/L,and 40 cases （83.3%） whose sera PA was more than 250mg/L before treated.Of all infants with neonatal infectious diseases, their sera HSCRP increased, while their sera PA decreased. Expeeially their changes were outstanding in the patients with neonatal septicemia,purulent meningitis, infectious pneumonia, there were significent differences in sera HSCRP and PA between before and after treated.There were no significent difference in sera HSCRP and PA among infants with enteritis,umbillcal and skin infections.Their sera HSCRP decreased and PA increased gradually when their infections were controlled and their symptom and sign were alleviated. Their sera HSCRP was less than 3mg/L,PA was more than 250mg/L when all infants were cured.Conclusion The changes of HSCRP and PA may be an index of diagnosis, treatment and prognosis in neonatal infectious diseases.
出处
《四川医学》
CAS
2005年第9期938-939,共2页
Sichuan Medical Journal
关键词
新生儿
感染
高敏感C反应蛋白
前白蛋白
检测
high-sensitivity c-reactive protein
prealbumin
infant
newborn
infection
