摘要
【目的】研究p33ING1基因表达与皮肤鳞状细胞癌的发生、发展的关系。【方法】应用免疫组化检测本院1999~2004年收治的35例皮肤鳞状细胞癌及25例原位鳞癌(Bowen病)组织中的p33ING1表达情况。【结果】皮肤鳞状细胞癌p33ING1蛋白表达阳性率为42.9%(15/35),明显低于正常组的82.9%(29/35),两者比较差异有显著性(χ2=11.99,P<0.05)。其原位鳞癌中阳性表达为56%(14/25),同样明显低于正常组织的阳性率82.9%(29/35),两者比较差异有显著性(χ2=5.18,P<0.05)。【结论】p33ING1蛋白在皮肤鳞状细胞癌组织中的表达下降,提示p33ING1蛋白在皮肤鳞状细胞癌的发生、进展中有重要意义,并有可能成为其肿瘤检测蛋白之一。
[Objective]To investigate the expression ot p33^ING1 protein rate in skin squamous cell carcinoma and its clinical significance. [Methods]All samples of normal and cancer tissues from 95 patients were detected for their protein expression levels of p33^ING1 with the SP immunohistochemical staining. [Results]The positive rate of p33^ING1 in cutaneous squamous cell carcinoma was 42.9%. significantly lower than that of normal skin tissue（82.9%, P〈0.05）, And the expression of p33^INH1 was lower in Bowen disease tissues（56%） than that of normal tissues（82.9%）. [Conclusion]The low expression of p33^ING1 in carcinoma may be important fators related to carcinogenesis,development of cutaneous squamous cell carcinoma.
出处
《医学临床研究》
CAS
2005年第9期1197-1199,共3页
Journal of Clinical Research
关键词
癌
鳞状细胞
皮肤肿瘤
肿瘤蛋白质类
carcinoma, squamous
skin neoplasms
neoplasm proteins
