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Ca^(2+)-CaN-NFAT信号通路在心肌肥大中的作用及研究进展 被引量：5

Role of Ca^(2+)-CaN-NFAT Signaling Pathways in Cardiac Hypertrophy
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摘要 钙调神经磷酸酶(calcineurin,CaN)是Ca2+的下游因子,在细胞内钙升高引起的心肌肥大中有重要作用。现综述Ca2+CaN及其下游因子活化T细胞核因子3(NFAT3)和锌指转录因子(GATA4)在心肌肥大中的作用及近年的研究进展。 Calcineurin is the downstream factor of calcium,which is involved in the cardiac hypertrophy induced by elevating intracel- lular calcium. In the article, the advances in studing on the calcinerurin and its downstream factor, nuclear factor of activated T cell 3 （ NFAT3） and GATA4 in cardiac hypertrophy were summarized.
作者 蒋青松 周岐新 黄燮南
机构地区 重庆医科大学药理教研室 合肥医学院药理教研室
出处 《心血管病学进展》 CAS 2005年第B08期122-126,共5页 Advances in Cardiovascular Diseases
关键词 钙调神经磷酸酶 心肌肥大 信号通路 Calcineurin Cardiac hypertrophy Signal pathway
分类号 R541 [医药卫生—心血管疾病]
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参考文献30

  • 1Kudoh S, A kazawa H ,Takano H ,et al. Stretch-modulation of secnnd messengers:effects on cardiomyncyte ion transport [ J ]. Prog Binphys Mnl Biol, 2003,82 ( 1-3 ) :57-66.
  • 2Frey N, McKinsey TA, Olson EN. Decoding calcium signals involved in cardiac growth and function [J]. Nat Med,2000,6( 11 ):1221-1227.
  • 3de Windt L J, Lim HW, Haq S,et al. Calcineurin promotes protein kinase C and c-jun N H2-terminal kinase activation in the heart, cross-talk between cardiac hypertrophic signaling pathways [J].J Biol Chem,2000,275(18):13571-13579.
  • 4Bers DM,Perez-Reyes E. Ca^2 + channels in cardiac myocytes:srucre and function in Ca^2 + influx and intracellular Ca^2 + release [ J ]. Cardiovasc Res,1999,42( 2 ) :339-360.
  • 5Ohno M, Fomerod M, Mattaj IW. Nucleocytoplasmic transport :the last 200 nanometers [ J ]. Cell, 1998,92 ( 3 ) :327 -336.
  • 6Parker I, Wier WG. Variability in frequency and characteristics of Ca^2 + sparks at different release sites in rat ventricular myocytes [ J ]. J Physiol, 1997,505(Pt2) :337-344.
  • 7Schulz RA,Yutzey KE. Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development [ J]. Dev Biol,2004,266( 1 ) :1-16.
  • 8Guerlni D. Calcineurin :not just a simple protein phosphatase [ J]. Biochem Binphys Res Commun, 1997,235 ( 2 ) : 271-275.
  • 9Zhang WG. Old and new tools to dissect calcineurin's role in pressure-overload cardiac hypertrophy [ J ]. Cardiovasc Res,2002,53 ( 2 ) : 294-303.
  • 10Lai MM, Bumett PE ,Wolosker H et al. Cain ,a novel physiologic protein inhibitor of calcineurin [ J ]. J Biochem, 1998,273 ( 29 ) : 18325-18331.

二级参考文献29

  • 1Guerini D. Calcineurin, not just a simple protein phosphaltase. Biochem Biophys. Res Commun, 1997, 235 (2) : 271-275.
  • 2Klee CB, Ren H, Wang X. Regulatiolt of the calmodulin stimulated protein phosphatase, calcineurin. J Biol Chem, 1998, 273 (22) : 13 367-370.
  • 3Lai MM, Burnett PE, Wolosker H, Blackshaw S, Snyder SH. Cain, a novel physiologic protein inhibitor of calcineurin.J Biol Chem, 1998, 273 (29):18 325-331.
  • 4Omura M, Yamaguchi M. Inhibition of Ca2 +/calmodulin-dependent phosphatase activity, by regucalcin ill rat liver cytosal involvement of calmodulin binding. J Cell Biol Chem, 1998, 71 (1): 140-148.
  • 5Lim HW, New L, Han J, Molkentin JD. Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes. J Biol Chem, 2001, 276 (19): 15913-919.
  • 6Ranger AM, Crusby MJ, Hodge MR, Canvallese EM. de la Brousse FC, Hoey T, et al. The transcription factor NF-ATc is essential for cardiac valve formation. Nature, 1998, 392 (6672): 186-190.
  • 7Graef IA, Chen F, Chen L, Kuo A, Carbtree GR. Signal transduced by Ca (2+ ) /calcineturin and NFATc3/c4 pattern the developing vasculature. Cell,2001, 105 (7): 863-875.
  • 8Wilson AJ, Jabr RI, Clapp LH. Calcitum modulation of vascular smooth muscle ATP-sensitive K + channels: role of protein phosphatase-2B. Cire Res, 2000,87(11):1 019-025.
  • 9Arun Bandyopadhyay, Dong Wook SHIN, Jung On AHN, Do Han KEM. Calcineurin regulateds ryanodine receptor/Ca2 + release channels in rat heart. J Biochem, 2000, 352:61-70.
  • 10Kamiya H, Okumura K, Ito M, Saburi 4 Y, Tomida T, Hayashi K, et al. Calcineurin inhibitor attenuates cardiac hypertrophy due to energy metabolic disorder. Can J Cardiol, 2001, 17(12): 1292-298.

共引文献13

同被引文献33

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心血管病学进展
2005年 第B08期

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