摘要
目的测定阿尔茨海默病(AD)患者在光刺激驱动下脑电图功率,并与安静状态下的脑电图功率比较,探讨AD的神经生理学变化.方法对35例临床诊断为AD的患者(AD组)和正常成人33例(对照组),测定安静状态和光刺激驱动条件下的脑电图脑电信号平均功率,并进行统计学比较.闪光刺激的频率为5,10和15 Hz.结果 10 Hz闪光刺激相对应的α频段(9.8～10.2 Hz),15 Hz闪光刺激相对应的β频段(14.8～15.2 Hz),AD患者的脑电图功率值比对照组值小(P＜0.05).比较在安静状态下的α2(9.0～12.8 Hz)和β1(14.0～18.8 Hz)频段的测试结果,发现上述差异在光刺激驱动条件下更加明显.结论在光刺激驱动下AD患者存在相对应的脑功能变化障碍,提示AD有视觉系统的功能障碍.脑电图光刺激驱动反应较常规脑电图更敏感,对临床诊断与疗效判断有意义.
Objective To examine electroencephalogram （EEG） response in photic driving in patients with Alzheimer＇s disease （AD） and to investigate the changes in neurophysiology for AD. Methods The average EEG signal power of 35 AD patients and 33 normal controls were determined at rest condition and photic driving fixed at 5, 10 and 15 Hz and compared. Results AD patients had a significantly lower power in the alpha band （9.8 -10.2 Hz） and beta band （14.2 -15.2 Hz） corresponding to photic stimulation at 10 and 15 Hz, respectively, than those of the normal controls （ P 〈 0.05）. Furthermore, the difference of absolute power of EEG between AD patients and subjects under the condition of photic stimulation is more significant than those under the condition of resting. Conclusions AD patients have EEG abnormalities in photic driving response, which suggests an impairment of visual functioning in AD. Photic driving response measurement plays an important role in clinical diagnosis and therapeutic effect assessment of AD and be more sensitive than routine EEG.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2005年第9期1011-1014,共4页
Chinese Journal of Gerontology
基金
浙江省科技计划项目(2004C30020)
浙江省卫生厅科研项目(2003B070)
关键词
阿尔茨海默病
脑电图
光驱动反应
Alzheimer＇s disease
Electroencephalogram
Photic driving response
