摘要
目的探讨LDL-C/HDL-C比值与冠脉病变程度和急性冠脉综合征的关系。方法回顾性地分析203例选择性冠状动脉造影的病人,其中冠心病组(冠状动脉狭窄至少有1支以上≥50%)139例,非冠心病组(冠状动脉狭窄<50%)64例,分析两组间血脂各项(LDL-C、HDL-C、LDL-C/HDL-C)是否有差异性;LDL-C、HDL-C、LDL-C/HDL-C与冠状动脉狭窄程度的相关性及与急性冠脉综合征的关系。结果(1)LDL-C、LDL-C/HDL-C冠心病组比非冠心病组高[LDL-C(2·71±0·81)mmol/L vs(2·33±0·95)mmol/L,P<0·01;LDL-C/HDL-C(2·43±0·66)vs(1·92±0·64),P<0·01];冠心病组HDL-C(1·17±0·29)mmol/L低于非冠心病组HDL-C(1·27±0·35)mmol/L,(P<0·05)。(2)LDL-C,LDL-C/HDL-C与冠状动脉狭窄程度呈微弱的正相关(RldL-c=0·159,P=0·024,RldL-c/hdL-c=0·213,P=0·002)。(3)LDL-C/HDL-C急性冠脉综合征组(2·61±0·85)比非急性冠脉综合症组(2·33±0·86)高(P<0·05),差异有显著性。结论(1)冠心病患者LDL-C、LDL-C/HDL-C升高、HDL-C降低。(2)LDL-C,LDL-C/HDL-C与冠状动脉狭窄程度呈微弱正相关。(3)LDL-C/HDL-C比值升高是急性冠脉综合症的一项比较常见的伴有脂质异常。
Objective To study the relationship between dyslipidemia and the morphologic changes of coronary arteries and acute coronary syndromes. Methods The patients with chest pain were divided by coronary angiography into abnormal coronary artery group （n= 139, stenosis in one main branch 50% ）, and normal group （stenosis〈50%, n = 64）. LDL-C, HDL-C, LDL-C/HDL-C and the degree of coronary artery stenosis were determined. Results （1） The levels of LDL-C, LDL-C/HDL-C ratio in abnormal coronary artery group were higher than that of normal group [LDL-C（2.71±0.81 vs 2.33 ± 0.95）mmol/L, P〈0.01; LDL-C/HDL-C ratio （2.43 ± 0.66 vs 1. 92±0. 64）mmol/L, P〈0.01]. The level of HDL-C in abnormal coronary artery group was lower [（1.17±0. 29 vs 1.27±0.35）mmol/L, P〈 0. 01 ]. （2）The levels of LDL-C, and LDL-C/HDL-C were weakly related with coronary artery stenosis degree（RIdL-c=0. 159, P=0. 024, RIdL-c/hdL-c =0. 213, P=0. 002）. （3）The acute coronary syndromes group had higher level of LDL-C/HDL-C（ 2.61±0.85）mmol/L than that of the non-acute coronary syndromes group [（2.33 ±0.86）mmol/L, P〈0.05]. Conclusion （1）The group of coronary heart disease patients had higher levels of LDL-C, LDL-C/HDL-C and lower level of HDL-C than that of the group of normal subjects. （2）The levels of LDL-C and LDL-C/HDL-C was positively related with the severity of coronary artery stenosis.
出处
《高血压杂志》
CSCD
北大核心
2005年第9期541-544,共4页
Chinese Journal of Hypertension
