摘要
为探索米非司酮抗早孕的最小有效剂量,对100例停经≤56天孕妇服不同剂量米非司酮进行了临床预试验。分为四组停经≤35天受试者分次服米非司酮7mg,配伍米索600μg,完全流产率95.4％;35天<停经≤56天受试者分次服米非司酮100mg,及125mg两组完全流产率均高于93％,而顿服米非司酮100mg完全流产率仅73.3％,与另三组有显著差异。提示:①米非司酮75mg分次服抗早孕具有良好的抗早孕前景,副反应小,可节省服药妇女经费。②顿服米非司酮100mg临床效果不佳。③分次服米非司酮100mg,停经天数可延长到56天,仍有良好流产效果。
The methods and results are as follows : One hundred early pregnant women with amenorrhea≤56 days were divided into 4 groups. Group 1 (n = 22, amenorrhea ≤ 35 days) :mifepristone 75 mg was given in two days and misoprostol 600 μg on the 3rd day. Group 2 (n = 15, amenorrhea 36 - 56 days):a single dose of mifepristone 100 mg and misoprostol 600 μg on the 3rd day. Group 3(n = 33,amenorrhea 36-56 days): mifepristone 100 mg(25mg b. I. d. )was given in two days and misoprostol 600 μg on the 3rd day. Group 4(n = 30,amenorrhea 36 - 56 days ): mifepristone 125 mg in two days and misoprostol 400 μg on the 3rd day.The complete abortion rate of each group was 95. 4% ,73. 3% ,100% ,93. 4%re-spectively. The bleeding pattern for three groups (group 1, 3, 4 ) was similar (P > 0.05).The side effects of group 1 was lower than that of other groups.Up to now mifepristone 75 mg is the minimum dose on the world for termination of early pregnancy.
出处
《中国计划生育学杂志》
1996年第2期86-88,共3页
Chinese Journal of Family Planning
关键词
米非司酮
米索前列醇
抗早孕
引产药
Mifepristone Misoprostol Termination of early pregnancy Minimum dose
