摘要
目的:观察帕罗西汀对腹泻型肠易激综合征(D-IBS)的疗效。方法:按罗马Ⅱ诊断标准选择45例腹泻型D-IBS 患者,给予帕罗西汀10mg/d,疗程12周。治疗前后分别评定D-IBS 主要症状、排便频率、粪便性状、汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)。结果:42例患者完成研究,胃肠道主要症状、HAMD、和HAMA 评分均明显减低,治疗前后差异有显著性(P<0.01)。大便次数、性状及腹痛在治疗1周后即明显缓解(P<0.05),而抑郁、焦虑及精神状态的改善在2周后统计学意义(P<0.05)。以上观察指标评分呈逐周下降趋势,按意图治疗(ITT)和按方案(PP)分析,治愈率为81.0%,总有效率为100%。结论:帕罗西汀能明显缓解胃肠道症状,改善精神状态,但二者并不完全同步。
Objective：To investigate efficacy of paroxetine in the treatment of diarrhea-predominant irritable bowel syndrome （D-IBS）. Methods：In a self-controlled trial, 45 patients with D-IBS symptoms according to the Rome II criteria were treated with paroxetine 10mg Qd for 12 weeks. The efficacy measures included D-IBS gastrointestinal symptoms, abnormal frequency or consistency of defecation, Hamilton Depression Scale （HAMD） and Hamilton Anxiety Scale （HA/VIA）. Results-42 cases completed 12 week therapy. The overall IBS symptoms, the Bristol stool consistency, stool frequency and abdominal pain were relieved significantly at week 2 （P〈0.05）. The reduction of HAMD and HAMA were statistically significant only after week 4 （P〈0.01 ）. The recovery rate was 81.0% in intention-to-treat （ ITT ） analysis, and total response rate was 100% in per-protocol （PP） analysis. Conclusion： Paroxetine can relieve both gastrointestinal and psychological symptoms, but GI symptoms were relieved earlier. Paroxetine is effective in treating D-IBS.
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2005年第8期561-563,共3页
Chinese Mental Health Journal
关键词
腹泻
腹泻型肠易激综合征
帕罗西汀
5-羟色胺
diarrhea-predominant
irritable bowel syndrome （IBS）
paroxetine
serotonin
