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嗜麦芽窄食单胞菌感染58例临床分析 被引量:6

Analysis of stenotrophomonas maltophilia infections in 58 cases
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摘要 目的研究住院患者嗜麦芽窄食单胞菌感染的分布、药敏、临床及细菌学疗效。方法回顾性分析58例嗜麦芽窄食单胞菌感染病人的临床情况。结果菌株对大部分抗生素耐药,对亚胺培南的耐药率为100%,临床有效率为70.7%,细菌清除率为69%。结论选择碳青霉烯类药物要慎重,明确的嗜麦芽窄食单胞菌感染要根据药敏选择抗生素,首选药物为三代头孢菌素+酶抑制剂及复方新诺明。 Objective To study the distribution, antimicrobial susceptibility, clinical and bacteriological efficacy of stenotrophomonas mahophilia infections.Methods We analysed the clinical efficacy of 58 patients infected with stenotrophomonas maltophilia retrospectively.Results The bacterium was resistant to most antibiotics, the resistant rate to Imipenem was 100%, The clinical effective rate was 70.7% and the bacterial eradication rate was 69% .Conclusios Carbapenems should be carefully selected for the treatment of infections. Antibiotics should be selected according to the results of antimicrobial susceptibility, Cephalosporin of third- generation plus enzymatic depressor and trimethoprim/sulfamethoxazole should be the fast choice.
出处 《中国急救医学》 CAS CSCD 北大核心 2005年第9期628-630,共3页 Chinese Journal of Critical Care Medicine
关键词 嗜麦芽窄食单胞菌 感染 耐药性 临床疗效 Stenotrophomonas maltophilia Infection Drug resistance Clinical efficacy
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  • 1Penzak SR, Abate BJ.Stenotrophomonas (Xanthomonas) maltophilia: a multidrug-resistant nosocomial pathogen[J]. Pharmacotherapy, 1997,17:293-301.
  • 2Todd S Krueger, Erin A Clark, David E Nix.In vitro susceptibility of Stenotrophomonas maltophilia to various antimicrobial combinations[J]. Diagnostic Microbiology and Infectious Disease,2001,41:71-78.
  • 3Munoz Bellido JL, Munoz Criado S, Garcia Garcia I, et al.In vitro activities of β-lactam-β-lactamase inhabitor combinations against Stenotrophomonas maltophilia: correlation between methods for testing inhibitory activity, time-kill curves and bactericidal activity[J]. Antimicrobial Agents and Chemotherapy, 1997,41:2612-2615.
  • 4Hancock REW. Resistance mechanisms in Pseudomonas aeruginosa and other nonfermentative gram-negative bacteria[J]. Clinical Infectious Disease, 1998,27(Suppl 1),S93-S99.

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