摘要
2型糖尿病是一种慢发性疾病，发病率占10％左右。胰岛素抵抗表现为胰岛素刺激后骨骼肌葡萄糖吸收相对下降，是该疾病的一个苇要方面。尽管这方面研究很尽力，但是胰岛素抵抗的分子机制仍然没有弄清楚。胰岛素主要促进GLUT4从内膜系统转运到细胞膜来刺激肌肉组织吸收葡萄糖。虽然发现很多分子参与胰岛素信号通路，但是联系GLUT4转位与胰岛素刺激之间的精确步骤尚未完全阐明。
Protein kinase C（PKCξ） is a member of the PKC family, serving downstream of insulin receptor and phosphatidylinositol（PI）3-kinase. Many evidences have shown that PKCξ plays an important role in activating glucose transport response. Not only insulin but also glucose and exercise can activate PKCξ through diverse pathways. PKCξ has been shown to be closelv related with insulin resistance in muscle and adipose tissues in patients with type 2 diabetes, Exploring the molecular mechanisms and pathways that PKCξ mediates glucose transport will highlight insulin signaling pathway.
