摘要
脂联素(ad iponectin)是来源于脂肪组织的脂肪细胞因子之一,具有抗炎、抗糖尿病、抗动脉粥样硬化和增敏胰岛素的作用。脂联素的这些效应必须通过脂联素受体1(Ad ipoR1)和Ad ipoR2的介导。近年的研究发现,Ad ipoR1在骨骼肌中有丰富表达,Ad ipoR2主要在肝中表达;Ad ipoR1和Ad ipoR2也在人和鼠的胰岛β细胞中表达,其水平与肝中类似,比骨骼肌更高;Ad ipoR1和Ad ipoR2也可在单核细胞和巨噬细胞中表达。过氧化物酶体增殖物激活受体-α(PPAR-α)、PPAR-γ和肝X受体(LXR)的激动剂以及生长激素(GH)可影响脂联素受体的表达和调节。
Adiponectin is one of the adipocytokines that are derived from adipose tissue. It has anti-inflammatory, anti-diabetic, anti-atherogenic and insulin-sensitizing effects. Its receptors AdipoR1 and AdipoR2 mediate the function of adiponectin. Recent researches show that AdipoR1 is abundantly expressed in skeletal muscles, whereas AdipoR2 is AdipoR2 are found to be expressed in human and predominantly expressed in the liver. Both AdipoR1 and AdipoR2 are found to be expressed in human and rat pancreatic β cells and the expression levels are similar to those in liver and higher than those in muscles; AdipoR1 and AdipoR2 can also be found in monocytes and macrophages. GH and agonists of PPAR-α, PPAR-γ and LXR also affect the exprssion and regulation of adiponectin receptors.
出处
《医学研究生学报》
CAS
2005年第9期841-844,共4页
Journal of Medical Postgraduates
关键词
脂肪细胞
脂联素
脂联素受体
基因表达
Adipocytokines
Adiponectin
Adiponectin receptors
Gene expression
