摘要
目的:研究急性早幼粒细胞白血病(acute promyelocytic leukemia,APL)合并出血的临床特点和防治方法。方法:回顾性分析63例APL患者的临床特点、实验室检查及疗效。结果:初诊时合并出血症状54例(85.7%),合并弥漫性血管内凝血(DIC)47例(74.6%)。早期死亡11例(17.5%),放弃治疗3例,完全缓解49例(77.7%)。结论:APL出血发生率高,全反式维A酸(ATRA)或复方青黛片的应用、血小板及凝血因子输注、抗DIC治疗可以减少早期出血病死率。
Objective： To explore the clinical features, prevention and treatment of hemorrhagic symptoms in patients with acute promyelocytic leukemia（APL）. Methods： The clinical features, laboraratory findings and curative effect of 63 cases of APL were analyzed retrospectively. Results： Fifty-four （85.7%） hemorrhage episodes were observed in the 63 cases of APL, including 11（ 17.5 96 ） early hemorrhagic deaths and 47 cases with disseminated intravascular coagulation（DIC）. Three cases quitted treatment after diagnosis and 49 （77.7 % ） cases gained complete remission. Conclusions： There is a high rate of hemorrhage in patients with APL. Administration of aU-trans retinoic acid or compound qingdai tablets, transfusion of platelet and coagulation factors and therapy for DIC can reduce the incidence of early hemorrhagic deaths.
出处
《蚌埠医学院学报》
CAS
2005年第5期438-439,共2页
Journal of Bengbu Medical College
