摘要
目的:探讨早期应用多巴胺、酚妥拉明持续缓慢静脉滴注(静滴)在高危早产儿治疗中的临床探讨.方法:将活产的存在潜在休克的高危早产儿83例作为观察对象.随机分成早期干预组42例和对照组41例,对照组采取保暖、预防感染、支持治疗、预防呼吸暂停及对症处理等.干预组在以上的基础上加用多巴胺每次0.5 mg/kg、酚妥拉明每次0.25 mg/kg,用5%葡萄糖注射液以多巴胺每分钟5～10 μg/kg速度持续缓慢静滴,每8 h或每12 h一次.观察两组早产儿的硬肿症发生率及病死率.结果:早期干预组病死7例,对照组病死15例,差异有显著性(P＜0.05);早期干预组硬肿症发生率为28.57%,对照组为60.98%,差异亦有显著性(P＜0.01).结论:在观察肢端温度及末梢循环的情况下,早期应用多巴胺、酚妥拉明可以预防早产儿硬肿症的发生,减少早产儿病死.
Objective：To explore the role of administration of dopamine and phentolamine dropping in vein persistently and slowly in treatment of premature infants in early period. Methods：Eighty-three live birth premature infants with high risk of latent shock were randomly divided into early intervention group（42 cases） and control group（41 cases）. For the control group, the infants were kept warm,protect from infection and respiration pause, and dealt with their symptoms. For the intervention group, dopamine 0.5 mg·kg^-1·time^-1, phentolamine 0.25 mg·kg^-1 time^-1 were added. Dopamine 5 - 10 μg·kg^-1 min^-1 with 5% glucose were administered to drop in vein q8h or ql2h persistently and slowly. The scleroderma incidence rate and the death rate of the premature infants of the two groups were observed. Results： There were 7 fatality cases in the early intervention group, but 15 fatality cases in the contrast group. The difference was significant（ P 〈 0.05）. Scleroderma incidence rate in early intervention group was 28.57 %, while it was 60.98% in the contrast group. There were distinct differences between the two groups（P 〈 0.01）Conclusions： Dopamine arid phentolamine are effective in preventing infant sclerederna arid reducing the fatality of prmaature infants while their acral tmaperature arid peripheral circulation should be observed during the administration.
出处
《蚌埠医学院学报》
CAS
2005年第5期411-413,共3页
Journal of Bengbu Medical College
关键词
婴儿
早产
疾病
药物疗法
多巴胺
酚妥拉明
infant, premature, diseases
drug therapy
dopamine
phentolamlne
