摘要
目的:评价NP(去甲长春碱+顺铂)、GP(吉西他滨+顺铂)两种方案治疗晚期非小细胞肺癌的疗效及毒副反应.方法:40例晚期非小细胞肺癌随机分为两组,NP组20例,去甲长春碱25 mg/m2第1、5天静脉滴注,顺铂80 mg/m2第2～4天静脉滴注;GP组20例,吉西他滨800 mg/m2第1、5天静脉滴注,顺铂80 mg/m2第2～4天静脉滴注;每4周为1周期,连用2周期后评价疗效.结果:NP、GP的有效率分别为35.0%和40%(P>0.05).NP组白细胞下降静脉炎发生率高于GP组;GP组血小板下降发生率高于NP组(P<0.05和P<0.01).结论:NP、GP方案治疗晚期非小细胞肺癌的有效率相似,毒性可耐受.
Objective：To evaluate the efficacy and toxicity of combination chemotherapy of vinorelbine plus cisplatin and gemcitabine plus cisplatin in the treatment of advanced non-small cell lung cancer（NSCLC）. Methods：Forty patients with NSCLC were devided into two groups, Twenty patients received NP（vinorelbine 25 mg/m^2 iv dl. d5 and cisplatin 80 mg/m^2 d2 - d4）. Twenty patients received GP（gemcitabine 800 mg/m^2 iv dl, d5 and cisplatin 80 mg/ms d2- d4）. Both groups were recycled every 4 weeks and the therapeutic effect were evaluated after two cycles. Results：The objective response rate was 35% in NP group and 40% in GP group（P〉0.05）. The leukopenia and the incidence of vein irff/ammation were higher in the NP group than in the GP group, while thrombocytopenia occurred more frequently in the GP group（ P 〈 0.05 and P 〈 0.01 ）. Conehltsions： No significiant difference was observed in response rate between two groups, The side effects were tolerated.
出处
《蚌埠医学院学报》
CAS
2005年第5期400-401,共2页
Journal of Bengbu Medical College
关键词
癌
非小细胞肺
肿瘤倩物疗法
去甲长春碱
吉西他滨
顺铂
cancer, non-small cell lung
neoplawrts/drug therapy
vinorelbine
gemcitabine
clsplatin
