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侧脑室注射内吗啡肽-1对大鼠心功能的影响 被引量：1

Influence of intracerebroventricular administraction of endomorphine-1 on left venteicular systolic pressuer in rats
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摘要 目的:观察侧脑室注射内吗啡肽-1(EM-1)对麻醉大鼠心功能的影响,探讨其作用机制。方法:麻醉大鼠侧脑室埋植导管给药,右颈总动脉插管测心功能。结果:侧脑室注射EM-1,Cyprodime敏感减弱大鼠左心室功能。结论:侧脑室注射EM-1能引起麻醉大鼠在体心功能下降而降低动脉血压,此效应由阿片受体介导,通过兴奋迷走神经所致。 Objective：To observe the influence of intracerebroventricular administraction of endomorphine-1 on the left venteicular systolic pressuer（LVSP） in anesthetized rats and to assess its mechanism. Methods：Variations of LVSP were observed after injecting andomorphin-1 in anesthetized rats. Results：Endomorphin-1 decreased the LVSP. The decrease in LVSP was blocked by cyprodime. Cortelusions： Intracerebroventricular administration of endomorphin-1 produces depression on the LVSP in the anesthetized rats, which is mediated by opioid receptor,associated with the central mcholinoceptor and the excitation of the vagus.
作者 胡杰 汪思应 李正红
机构地区 安徽医科大学 蚌埠医学院生理学教研室
出处 《蚌埠医学院学报》 CAS 2005年第5期390-392,共3页 Journal of Bengbu Medical College
基金 安徽省教育厅自然科学研究资助项目(2002kj205)
关键词 吗啡衍生物 内吗啡肽 受体 内啡肽 左心室收缩压 大鼠 morphine derivatives endomorphin receptors,endorphin left venteicular systolic pressuer mts
分类号 R971 [医药卫生—药品]
  • 相关文献

参考文献13

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共引文献4

同被引文献14

  • 1Champion HC,Bivalacqua TJ,Lambert DG,et al.Endomorphin1 and 2,the endogenous μ-opioid agonists,produce biphasic changes in systemic arterial pressure in the cat[J].Life Sci,1998,63(9):131-136.
  • 2Rialas CM,Fimiani C,Bilfinger TV,et al.Endomorphin-1 and -2 inhibit human vascular sympathetic norepinephrine release:Lack of interaction with μ3 opiate receptor subtype[J].Acta Pharmacol Sin,1998,19(5):403-407.
  • 3Irnaten M,Aicher SA,Wang J,et al.μ-opioid receptors are located postsynaptically and endomorphin-1 inhibits voltage-gated calcium currents in premotor cardiac parasympathetic neurons in the rat nucleus ambiguus[J].Neuroscience,2003,116(2):573-582.
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  • 6Champion HC,Zadina JE,Kastin AJ,et al.Endomorphin 1 and 2,the endogenous ligands for theμ-receptor,decrease cardiac output and peripheral resistance in the rat[J].Peptides,1997,18(9):1 393-1 397.
  • 7Czapla MA,Champion HC,Zadina JE,et al.Endomophin 1 and 2,endogenous μ-opioid agonists,decrease systemic arterial pressure in the rat[J].Life Sci,1998,62(13):PL175-PL179.
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蚌埠医学院学报
2005年 第5期

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