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Tim家族的研究进展及与哮喘的关系 被引量：4

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摘要 T细胞免疫球蛋白域粘蛋白域蛋白(Tim)基因是新近发现的一类基因家族,研究表明Tim家族与T细胞免疫反应及Th1和Th2细胞分化有关,可能对哮喘和自身免疫病的发生与发展起重要作用,本文拟就有关内容作一综述。
作者 张才成 吴健民（审校） 崔天盆（审校）
机构地区 华中科技大学同济医学院附属协和医院检验科（硕士研究生） 华中科技大学同济医学院附属协和医院检验科
出处 《国外医学（免疫学分册）》 2005年第5期316-320,共5页 Foreign Medical Sciences(Section of Immunology Foreign Medical Sciences)
关键词 Tim基因 哮喘 TH细胞 多态性
分类号 R562.25 [医药卫生—呼吸系统]
  • 相关文献

参考文献20

  • 1Mclntire JJ, Umetsu SE, Akbari O, et al.. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family[J]. Nat Immunol,2001,2(12): 1109-1116.
  • 2Kuchroo VK, Umetsu DT, DeKruyff RH, et al.. The TIM gene family: emerging roles in immunity and disease[ J ]. Nat Rev Immunol, 2003, 3(6) :454-462.
  • 3Bailly V, Zhang Z, Meier W, et al. Shedding of kidney injury molecule- 1, a putative adhesion protein involved in renal regeneration[J]. J Biol. Chem,2002,277(42) :39739-39748.
  • 4Kumanogoh A, Marukawa S, Suzuki S, et al. Class Ⅳ semaphorin Sema4A enhances T-cell activation and interacts with Tim-2[J]. Nature,2002,419(6907): 629-633.
  • 5Coyle AJ, Gutierrez-Ramos JC. The role of ICOS and other costimulatory molecules in allergy and asthma[J]. Springer Semin Immunopathol,2004,25 (3-4): 349-359.
  • 6Shakhov AN, Rybtsov S, Tumanov AV, et al.. SMUCKLER/TIM4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling[J]. Eur J Immunol,2004,34(2) :494-503.
  • 7Matricardi PM,Rosmini F,Panetta V,et al. Hay fever and asthma in relation to markers of infection in the United States[J] .J Allergy Clin Immunol,2002,110(3) :381-387.
  • 8Han WK, Bailly V, Abichandani R, et al. Kidney injury molecule-1 (KIM-1) :a novel biomarker for human renal proximal tubule injury [J]. Kidney Int, 2002,62(1): 237-244.
  • 9Van Eerdewegh P,Little RD,Dupuis Let al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness[J]. Nature,2002,418(6896) ;426-430.
  • 10Moss RB,Janssen E,Nieto D,et al. Inhibition of Airway Inflammation by TIM-1 Antibody in a Murine Model of Asthma[J] .J Allergy Clin Immunol,2005,115(4): 891.

同被引文献43

  • 1任碧琼,邹国英,郭田生.酸性同工铁蛋白的应用价值与研究进展[J].国外医学（临床生物化学与检验学分册）,2005,26(1):23-25. 被引量：3
  • 2胡丽华,崔天盆,张才成,王琳.湖北地区汉族变应性哮喘患儿TIM-3启动子区基因多态性研究[J].中华检验医学杂志,2006,29(2):125-127. 被引量：12
  • 3洪晓武,储以微,熊思东.TIM家族成员对Th细胞分化的调节作用[J].现代免疫学,2006,26(2):161-163. 被引量：1
  • 4夏义平,崔天盆,吴健民.TIM4基因多态性与湖北汉族变应性哮喘的相关性研究[J].中华医学遗传学杂志,2007,24(2):213-216. 被引量：5
  • 5McIntire JJ , Umet su SE , Akbari O , et al. Identification of Tapr ( an airway hyperreactivity regulatory locus ) and the linked Tim gene family. Nat Immunol, 2001, 2(12) :1109-1116.
  • 6Cao E, Zang X, Ramagopal UA, et al. T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. Immunity, 2007, 26 (3) :311-321.
  • 7Feng BS, Chen X, He SH, et al. Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)-1/TIM4 interaction as a therapeutic strategy in a dendritic cell-induced peanut allergy model. J Allergy Clin Immunol, 2008, 122( 1 ) :55-61.
  • 8Umetsu SE, Lee WL, McIntire JJ, et al. TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat Immunol, 2005, 6(5) :447-454.
  • 9Sabatos CA, Chakravarti S, Cha E, et al. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol, 2003, 4 ( 11 ) : 1102-1110.
  • 10Sanchez-Fueyo A, Tian J, Picarella D, et al. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol, 2003, 4 ( 11 ) : 1093-1101.

引证文献4

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国外医学（免疫学分册）
2005年 第5期

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