摘要
目的探讨胃肠道间质瘤的诊治、临床病理学及免疫组化特征。方法收集1998～2005年收治的41例胃肠道间质瘤的临床病理学资料,进行免疫组织化学染色,标记抗体为CD117、CD34、SMA和S100蛋白。结果危险程度极低2例,低度危险8例,中度危险19例,高度危险12例。肿瘤是否浸润黏膜肌层或浆膜层与危险程度相关(χ2=4.85,P<0.05)。CD117、CD34、SMA和S100蛋白阳性表达分别为90%、83%、37%和25%,其阳性表达率与肿瘤危险程度无关(χ2=0.34、0.04、0.01、0.02,P>0.05)。结论Fletcher的危险程度分类符合临床治疗与预后的需要。肿瘤浸润黏膜肌层或浆膜层是危险性的重要指标,而免疫表型与危险程度无关。肿瘤完全切除联合使用伊马替尼是改善预后的关键。
Objective To investigate the clinicopathologic and immunohistochemical features of gastrointestinal stromal tumors （GISTs）. Methods The diagnosis and treatment results of GISTs were studied,and elinieopathologie features and immunohistoehemieal expressions of CD117 ,CD34 ,smooth muscle aetin （SMA） and S-100 protein were detected in 41 cases of GISTs from 1998 to 2005. Results According to the Fletcher classification,2 cases were very low risk,8 cases were low risk, 19 eases were intermediate risk and 12 cases were high risk. The infiltration to the muscular layer of mucosa or the serous layer was correlated with the risk of GISTs significantly （χ^2 = 4. 85, P 〈 O. 05 ）. The percentage of positivity of CD117 ,CD34 ,SMA and S-100 protein was 90%,83%,37% and 25% ,respectively. There was no significant difference in the expression of CD117, CD34, SMA and S-100 protein among all the different risk groups （χ^2 = 0. 34,0. 04,0. 01, 0.02, P 〉0. 05 ）. Conclusion The different risk categories of Fletcher for GISTs are coincidence with the requirement of clinical treatment and prognosis. The infiltration to the muscular layer of mueosa or the serous layer is an important predictor of the risk of GISTs, and the immunophenotype is not a predictor. Total resection of tumor combined with imatinibmesylate is the key way to improve the prognosis.
出处
《中国实用外科杂志》
CSCD
北大核心
2005年第9期548-550,共3页
Chinese Journal of Practical Surgery
关键词
胃肠道间质瘤
免疫组化分析
Gastrointestinal stromal tumors
Immunohistochemistry
