摘要
离子通道是细胞膜上控制离子进出的功能蛋白,在细胞生命活动中发挥重要作用.离子通道具有对离子的选择性、通透的饱和性和开关的可控制性等特点;膜电压的变化、机械刺激和某些信号分子都可以调控离子通道开关;离子通道担负着离子吸收、渗透压调控、电冲动的形成和信号转导等重要的生理功能.离子通道的结构或功能失常会导致一些严重的疾病,对离子通道进行研究,寻找和设计调控离子通道的有效药物是治疗相关疾病的重要手段.
The ion channels are functional proteins in cell membrane which modulate ion influx or elflux, they play an important role in cellular metabolic processes. Ion channels have some physiological features, such as selectivity to specific ions, the saturation of permeability, and their gating can be modulated. The ion channels can be gated by trans-membrane voltage, mechanical stimulation and some signal molecules. Ion channels participated in some important physiological functions, such as ion absorbing ,osmotic regulating,generation of electric impulse and signal transduction. The abnormal structure or function of ion channels may result in some serious diseases. Therefore, the investigation on ion channels in order to seek or design some reagents which can modulate ion channels is an important pathway to cure related diseases.
出处
《河北师范大学学报（自然科学版）》
CAS
北大核心
2005年第5期519-522,共4页
Journal of Hebei Normal University：Natural Science
基金
国家自然科学基金资助项目(30370728)
河北省自然科学基金资助项目(C2005000173)
关键词
离子通道
生理功能
疾病
ion channel
physiological function
disease
