摘要
合成了９个Ｒ_２ＳｎＬ_２型（Ｒ＝乙基、正丁基和苯基；ＨＬ＝苯甲酰异羟肟酸，对羟基苯甲酰异羟肟酸和水杨酰异羟肟酸）和６个［Ｒ_２ＳｎＬ］_２Ｏ型（Ｒ＝乙基、正丁基；ＨＬ同上）二烃基锡新配合物。测定了它们的分子量、红外光谱和核磁共振谱，着重研究了这些配合物的体外抗癌活性。结果表明，这二类配合物对人白血病ＨＬ－６０，艾氏腹水和Ｓ－１８０癌细胞有很好的抑制能力。初步探讨了结构－抗癌活性间的关系。
Nine R_2 SnL_2-type(R=Et,n-Bu and Ph;HL=Benzohydroxamic acid,p-Hydro-xybenzo-hydroxamic acid and Salicylhydroxamic acid) and six [R_2Sn (L)]_2O-type diorganotin complexes have been prepared and characterized by elemental analysis,molecular weight,IR and 1￣H NMR spectra.The antitumor activity of these new complexes have been studied.The results show that these complexes exhibit better antitumor activity invitro against HL-60 Leukemic tumor cells,Ascite tumor cells and S-180 tumor cells.The structure-activity relationship is discussed.
基金
国家自然科学基金
南京大学配位化学国家重点实验室资助
关键词
配合物
芳香异羟肟酸
合成
抗癌活性
锡
diorganotin complex,arylhydroxamic acid,synthesis,characterization,antitumor activity
