摘要
^（９９ｍ）Ｔｃ－ＥＣＤ是目前脑显像剂中一种较为理想的放射性诊断药物。本文介绍了从基本原料（Ｌ）半胱氨酸开始合成配体ＥＣＤ（Ｎ，Ｎ＇－乙撑－双－Ｌ半胱氨酸乙酯），采用锡作还原剂实现了一步法^（９９ｍ）Ｔｃ标记ＥＣＤ，并对制备的^（９９ｍ）Ｔｃ－ＥＣＤ进行了初步动物实验以评价其生物学性能。
By using L-cysteine as a starting reagent, the ECD ligand was synthesized by three-step reactions. To overcome oxidation and hydrolysis drawbacks of using Sn(Ⅱ) as reduction agent, we use Sn(0) instead of Sn(Ⅱ) to prepare ￣(99m)Tc-ECD and the preliminary animal evaluation showed that this method was preferable.
出处
《化学研究与应用》
CAS
CSCD
1996年第2期203-206,共4页
Chemical Research and Application
