阿司匹林抵抗机理及防治研究进展
摘要
阿司匹林是一种抗血小板聚集药物。但据研究证明阿司匹林亦有不能很好地抑制血小板聚集的现象,这种现象即为阿司匹林抵抗。本文重点讨论了阿司匹林抵抗的机制,并对其临床研究、检测及防治作了介绍。
出处
《国外医学（老年医学分册）》
2005年第5期220-223,共4页
Foreign Medical Sciences(Geriatrics)
参考文献12
-
1Patrono C, Coller B, Dalen JE et al. Platelet- active drugs: the relationships anaong dose, effectiveness, and side effects. Chest, 2001; 119: 39s-63s.
-
2Chamorro A, Escolar G, Revilla M et al. Ex vivo response to aspirin differs in stroke patients with single or recurrent events: a pilot study. J Neural Sol, 1999; 171:110-114.
-
3Hirsh J, Dalen JE, Guyatt G et al. Low- dose and high -dose acetylsalicylic acid for patients undergoing carotid endarterecomy: a randomised controlled trial. Lancet,1999; 353:2179-2184.
-
4Fitz Gerald GA. Parsing an enigma: the pharmacodynamics of aspirin resistance. Lancet, 2003;361:542~544.
-
5Kawasaki T, Ozeki Y, Igawa T et al. Increased platelet sensitivity to collagen in individuals resistant to low- dose aspirin. Stroke, 2000; 31(3): 591-595.
-
6Macchi L, Brabant S. Resistance to aspirin in vitro is associated with increased platelet sensitivity to adenosine diphosphate. Thromd Res, 2002; 107 (1-2): 45-49.
-
7Eikelboom JW, Hirsh J, Weita JI et al. Aspirin - resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. Circulation, 2002;105:1650-1655.
-
8Zimmermann N, Kienale P, Weber AA et al. Aspirin resistance after coronary artery bypass grafting. Thorac Cardiovasc Surg, 2001; 121:982-984.
-
9Macchi L, Christiaens L, Brabant S et al. Resistance in vitro to low - dose aspirin is associated with platelet P1AI (GP Ⅲa) polymorphism hut not with C807T (GP I a/Ⅱa) and C- 5T Kozak (GP Ⅰ alpha) polymorphisms. Am Coll Cardiol, 2003; 42:1115-1119.
-
10Khatereh M, Wuillemin, Walter A. Association of two silent polymorphisms of platelet glycopmtein I a/Ⅱ a receptor with risk of myocardial infarction: a case - control study, lancet, 1999; 351:351-353.
-
1张予,张覃沐.阿霉素诱导的心脏毒性的机理及防治[J].癌症,1991,10(3):241-243. 被引量：14
-
2韩彦民.顺铂的肾毒性机理及防治措施[J].医学信息（医学与计算机应用）,1999,12(5):43-45. 被引量：2
-
3潘才桃.浅谈青霉素过敏性休克的机理及防治措施[J].中南工学院科技通讯,1996,12(1):41-41.
-
4伊文.为什么有的人会出现阿司匹林“抵抗”[J].老同志之友（上半月）,2006,0(6):47-47.
-
5辛秀俊,刘英祥,宋铁雄.泛影葡胺的不良反应及防治[J].护理研究,2001,15(2):70-71. 被引量：4
-
6陆国才,袁伯俊,陆德如.白细胞介素-2的毒性[J].国外医学（药学分册）,1991,18(1):28-31.
-
7章咏裳,鲁波,周惜才,李家贵,周四维,叶章群,庄乾元,曾进,杨为民,赵建军.FK506肾毒性的机理探讨及其防治研究[J].中华泌尿外科杂志,1996,17(6):345-348. 被引量：2
-
8王燕,陶泽璋.氨基糖苷类抗生素耳毒性的机理及防治措施[J].国外医学（耳鼻咽喉科学分册）,2005,29(6):392-395. 被引量：6
-
9陈凡,苏润毅.体外循环心脏手术鱼精蛋白反应[J].心血管病学进展,2003,24(1):21-23. 被引量：13
-
10王俊伟.阿司匹林抵抗的产生机制与防治策略[J].山西医药杂志（上半月）,2008,37(9):813-814. 被引量：1
