小胶质细胞在帕金森病发病学中的作用
摘要
帕金森病是仅次于阿尔茨海默病的神经系统退行性疾病,其发病原因尚未明确,目前越来越多的研究关注小胶质细胞激活在帕金森病发病学中的作用。多种原因激活小胶质细胞后,通过炎症反应和氧化应激机制引起黑质多巴胺能神经元死亡。美满霉素、地塞米松、纳洛酮、水飞藜素以及COX-2抑制剂等可以抑制小胶质细胞的激活,保护多巴胺能神经元免受氧化应激损伤,此类抑制小胶质细胞激活的药物有可能成为帕金森病神经保护的有效药物。
出处
《国外医学（老年医学分册）》
2005年第5期211-214,共4页
Foreign Medical Sciences(Geriatrics)
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