摘要
目的研究连续性肾脏替代治疗(CRRT)对多器官功能障碍综合征(MODS)患者C-反应蛋白(CRP)和前白蛋白(PA)水平的影响,探讨其对MODS的治疗作用和机理。方法将40例MODS患者随机分为治疗组(19例)和对照组(21例)。治疗组在常规综合保守治疗基础上使用CRRT,连续治疗3 d;对照组仅常规综合保守治疗。比较两组的临床疗效以及APACHEⅡ积分。同时比较两组外周C-反应蛋白(CRP)和前白蛋白(PA)在治疗前后各时相点的含量。结果治疗组总体疗效好于对照组;治疗组APACHEⅡ积分较对照组显著降低;治疗组外周血C-反应蛋白(CRP)在治疗后与治疗前以及对照组比较显著降低;CRRT治疗组治疗后第3天PA较治疗前呈显著升高趋势。结论CRRT治疗能有效降低CRP含量,治疗MODS疗效确切。
Objective To study the therapeutic effects of continuous renal replacement therapy （CRRT） to C-reactive protein（CRP） and prealbumin（PA） in the treatment of multiple organ dysfunction syndrome（MODS）. To study the therapeutic mechanism of continuous renal replacement therapy （CRRT） in the treatment of multiple organ dysfunction syndrome （MODS）.Methods Forty patients with MODS were divided at random into the CRRT group （therapeutic group, 19 patients） and the non-CRRT group （contrast group, 21 patients）. Both groups were treated by the conventional mode of therapy. The recovery time of organ function and APACHE Ⅱ scores of the two groups were compared. Simultaneously, the concentration of serum C-reactive protein and the concentration of serum prealbumin（PA） were also determined pro and post the therapy. Results The recovery time of organ function and APACHE Ⅱ scores were significantly decreased compared with those of the contrast group. The CRP detected at the end after CRRT were decreased significantly compared with those observed in pro CRRT and the contrast group.The PA detected at the end of 3d after CRRT were increased significantly compared with those observed in pro CRRT and the contrast group. Conclusions The above results show that the CRP overproduced during the development of MODS can be removed effectively by means of CRRT.CRRT has a good therapeutic effect on MODS.
出处
《实用临床医药杂志》
CAS
2005年第8期11-13,共3页
Journal of Clinical Medicine in Practice
基金
江苏省常州市卫生局基金资助项目(CS2005903)
