摘要
目的:观察静脉用足量右旋糖酐铁治疗腹膜透析的慢性肾功能衰竭病人铁缺乏贫血的有效性与安全性。方法:20例维持性腹膜透析病人,男性11例,女性9例,年龄(54±s12)a,采用一次足量右旋糖酐铁静脉滴注补铁,观察治疗前后血红蛋白(Hb)、血细胞比容(Hct)、血清铁蛋白(SF)、转铁蛋白饱和度(TS)的变化。结果:补铁总量为(1450±351)mg。治疗4,8wk,病人Hb上升(12±6),(24±7)g·L-1;Hct上升(0.050±0.010),(0.090±0.010);SF上升(288±87),(293±54)μg·L-1;TS上升(12±3)%,(11±3)%。无严重不良反应发生。结论:静脉足量右旋糖酐铁治疗腹膜透析病人铁缺乏贫血安全、有效。
AIM： To observe the efficacy and safety of intravenous infusion of total dose iron dextran in the treatment of anemia for peritoneal dialysis patients. tients METHODS： Twenty peritoneal dialysis pa- （M 11, F9; age （54 ±s 12）a） were once given intravenous infusion of total dose iron dextran. The hemoglobin （ Hb ）, hematocrit （ Hct ）, serum ferritin （SF） and trasferrin saturation（TS） were monitored before and after the treatment. RESULTS：After once total dose of iron dextran （ 1 450± 351 ） mg was infused intravenously. The following data were monitored at 4,8 wk, including Hb increased （ 12 ± 6 ）, （ 24 ± 7 ） g · L^-1 ;Hct increased （0.050 ±0.010） , （0.090 ± 0.010） ;SF increased （288±87）, （293±54）μg · L^-1;TS increased （12±3） %,（11±3） %. No serious adverse reaction occurred. CONCLUSION：Intravenous infusion of total dose iron dextran is effective and safe on correction of iron deficiency and improvement of renal anemia.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2005年第9期750-752,共3页
Chinese Journal of New Drugs and Clinical Remedies
