摘要
２６例伴有发作性症状的多发性硬化（ＭＳ），占同期ＭＳ住院患者的２１．５％（２６／１２１）。其中癫痫（１１例）和痛性强直（９例）是较常见的发作类型，而发作性复视、三叉神经痛、猝倒、发作性视力障碍、瘙痒及构音障碍等则相对少见。这些发作性症状的共同特点是症状突然发生，突然停止，持续时间短暂，呈刻板式反复发作，有的可以是ＭＳ的首发症状。可能的发病机理是由于中枢神经系统脱髓鞘损害，使神经轴索纤维间冲动发生横向扩散所致。卡马西平等抗痉药物多可控制发作。
Twenty-sixpatientswithparoxysmalsymptomsinmultiplesclerosis(MS)werere-ported.Theyconstituted21.48percentofour121admitedcasesofMS.Epilepsy(11cases)andpainfultonicspasm(9cases)werethemostcommontypesofatacks.Sometypesofatackssuchasparoxysmaldiplopia,trigeminalneuralgia,dropatacks,visiondisturbances,itchinganddysarthriawererelativelyrare.Thecommoncharacteristicsoftheseparoxysmalsymptomsconsistedofsuddenonset,shortdurationandrepetitiveandstereotypedpatern.In5patientstheseattacksweretheini-tialsymptomsofMS.ThepathogenicmechanismoftheparoxysmalsymptomsinMSprobablyisre-latedtoatransverselyspreadingimpulsesbyactivationoftheneuralaxonswithinthedemylinatinglesionintheCNS.ThesymptomscanbecontroledwithCarbamazepineorotherantiepileptics.
出处
《中华神经科杂志》
CAS
CSCD
1996年第1期26-28,共3页
Chinese Journal of Neurology
