摘要
本文对血小板超微结构、球结膜微循环与脑梗塞之间的关系进行了观察,进一步探讨血小板在脑梗塞发病中的动态改变及球结膜微循环的变化。结果显示:正常血小板呈园盘形或椭园形,中间为密度很高约2-3个致密体,并有多个溶酶体颗粒,以及较小的密度很高的许多糖元颗粒等。而患者组血小板形态、线粒体、致密斑颗粒、糖元颗粒与对照组比较均有显著变化或减少(P<0.001)。球结膜微循环的改变亦更明显,微血管血流慢、血管迂曲、形态不规则、局部扩张、细胞聚集等(P<0.01)。脑梗塞患者组血小板超微结构及球结膜微循环的改变与疾病程度成同步变化倾向。故脑梗塞患者除治疗缺血外,还应解除微循环障碍。
Platelet infrastructure and bulbar conjunctival microcirculation were measured in patients with cerebral infarction. The results showed that platelet morphology, chondriosome, compact granulation and glycogen granulation decreased significantly in patients when compared with control(P<0. 001). Microcirculation changed significantly in patients compared with control(P<0. 001). In conjunctival microcirculation the microangium dilated, blood flow was slow, blood vessel morphology was irregular and blood cell aggregated. These changes of platelet ultrastructure and bulbar conjunctival microcirculation were consistent with the degree of cerebral ischemic deterioration. The data suggested that microcirculation disturbance should be cured besides the treatment of ischemia.
关键词
脑梗塞
血小板
超微结构
微循环
Cerebral infarction Platelet ultrastructure Bulbar conjunctival microcirculation
