摘要
[目的] 探讨孕妇血清中乙型肝炎病毒DNA (HBV DNA) 含量与胎儿宫内感染发生率的关系. [方法] 用PCR法检测1 280例乙型肝炎表面抗原 (HBsAg) 阳性孕妇血清中HBV DNA含量及新生儿血清中HBsAg阳性情况. [结果] 1 280例血清中HBV DNA阳性孕妇所分娩的新生儿中,有425例HBsAg呈阳性,宫内感染率为33.20%.按母亲HBV DNA含量滴度的高低分为5×103～4,5×105～6,5×107～8拷贝/mL三组,分别为436例、398例、446例,其胎儿宫内感染分别为8例、82例、335例,感染率为1.83%、20.60%、75.10%,经统计学处理三组差异均有显著性(P<0.01). [结论] 孕妇血清中HBV DNA含量升高是胎儿发生乙型肝炎病毒感染的重要因素之一.
[ Objective ] To study the relationship of hepatitis B virus （ HBV ） DNA load in HBsAg positive pregnant women to intrauterine infection of their newborns. [ Methods] Serum HBV DNA were determined by dot - blot hybridization in 1280 HBsAg positive pregnant women. Serum HBsAg were tested by ELISA in their newborns within 24 hours after birth. [Results] 425 newborns of 1280 serum HBV DNA positive pregnant women were serum HBsAg positive . The incidence of intrauterine infection was 33.20%. Babies were devided into 3 groups ： group A （ n =436 ）, group B （ n = 398 ） and group C （ n = 446 ） according to the level of maternal HBV DNA load （5 × 10^3 -4,5 ×10^5-6 ,5 × 10^7 -8 eopies/mL, respectively ）. The number of infected newborns was 8, 82 and 335, the incidence of infection was 1.83% , 20.60% and 75. 10% respectively, their differences were statistically significant （ P 〈 0. 01 ）. [ Conclusion] Fetal exposure to high level of maternal HBV DNA is one of the important determinant of intrauterine infection.
出处
《上海预防医学》
CAS
2005年第9期428-429,共2页
Shanghai Journal of Preventive Medicine
关键词
妊娠
乙型肝炎病毒
宫内感染
Pregnancy
Hepatitis B virus
Intrauterine infection
