摘要
目的:研究静脉及硬膜外腔应用芬太尼对下腹部手术患者血中皮质醇及β-内啡肽含量的影响。方法:选择30例病人,ASAⅠ-Ⅱ级,诊断为子宫肌瘤,择期在硬膜外腔神经阻滞麻醉下行全子宫切除术,随机分成两组,静脉组和硬膜外组,每组15例,硬膜外麻醉平面固定后20min 使用辅助药物。静脉组:静脉注射芬太尼50μg,氟哌啶2.5mg。硬膜外组:硬膜外腔注入芬太尼50μg,静脉注射氟哌啶2.5mg。分别于麻醉前、麻醉平面固定后20min,给辅助药后20min、90min 测定血中皮质醇及β-内啡肽。结果:β-内啡肽含量在使用辅助药后20min,两组均有显著下降(p<0.01),而皮质醇含量在两组改变不明显。结论:两种途径给辅助药均能抑制β-内啡肽的分泌,因而对应激反应可能有部分抑制作用。
Objective： To investigate the effects of two regimens injecting fentanyl in locater abdominal surgery on cortisol and beta- endorphin.Methods： Thirty patients scheduled for elective laparohysterectomy were divided randomly into two groups： group μ receiving fentanyl 50μg by inyravenous（n= 15）,group Ⅱ receiving fentanyl 50μg by epidural（n= 15） .The operations were all performed under epidural anesthesia.Venous samples were taken to measure cortisol and β- endorphin by radioimmune assay at four time points： before operation, at 20min after fixation of the limits of epidural anesthesia at 20min and 90min after receiving fentanyl.Results： The concentration of β- endorphin is lower significantly in both groups as compared with that of prcoperation at 21min after receiving fentanyl（P〈 0.01）.But the concentration of cortisol doesn＇t change significantly.Conclusion： Two regimens injecting fentanyl can inhibit the secretion of endorphin and depress the stress responses partly.
出处
《黑龙江医药》
CAS
2005年第4期265-266,共2页
Heilongjiang Medicine journal
