摘要
目的:研究基质金属蛋白酶9(MMP-9)和组织型金属基质蛋白酶抑制因子1(TIMP-1)在膀胱移行细胞癌中的表达及其与肿瘤侵袭转移的关系。方法:采用免疫组织化学SP法检测56例膀胱移行细胞癌标本中MMP-9和TIMP-1的表达,并与肿瘤的临床及病理参数相比较。结果:在56例膀胱移行细胞癌中,MMP-9和TIMP-1的表达率分别为64.29%和57.14%,MMP-9表达率随肿瘤的临床分期、病理分级的升高而增加,TIMP-1表达率也呈上升趋势,两者间的表达存在轻度正相关。结论:MMP-9和TIMP-1的相互作用对于膀胱移行细胞癌的浸润转移发挥了重要作用,MMP-9可能成为早期无创诊断膀胱肿瘤的生物学指标。
Objective：To explore the expression of matrix metalloproteinase-9（MMP-9） and tissue inhibitor of metalloproteinase-1（TIMP-1） in bladder cancer and their clinical significance. Methods：The immunohistochemical staining assay was conducted to detect expression of MMP-9/TIMP-1 in 56 cases of bladder transitional cell carcinoma. The relationships among MMP-9/TIMP-1 expression, pathological grades and clinical stages of BTCC were also analyzed, Results：The positive rates of MMP-9 and TIMP-1 in bladder cancer are 64.29% ,57.14% respectively, MMP-9 expression increased significantly as the clinical stages and pathological grades, With the improvement of invasion tendency of BTCC.the expression of TIMP-1 was gradually increased, The two biomarkers have low positive correlation, Conclusions： The interaction between MMP-9 and TIMP-1 may play an important role in the invasive and metastatic progression of BTCC. Moreover, MMP-9 is regarded as a prognostic indicator of clinical early stage.
出处
《临床泌尿外科杂志》
2005年第9期577-580,共4页
Journal of Clinical Urology
