摘要
采用荧光偏振度测量方法,对健康人、冠心病及恶性肿瘤的血瘀证患者红细胞膜流动性作了检测。结果:冠心病和恶性肿瘤血瘀证患者的红细胞膜荧光偏振度数据和平均微粘度数据,均高于健康人(P 均<0.05)。表明冠心病和恶性肿瘤患者红细胞膜的流动性降低,使红细胞的变形能力减弱,从而影响血液在血管网中的流动性,促使微循环障碍的发生,这与中医的血瘀理论相符。
In order to approach the relationship between the TCM typology of blood stasis syndrome and the fluidity of human erythrocyte membrane,the fluidity of human erythrocyte membrane was examined in 14 healthy volunteers,21 patients with coronary heart disease and 14 patients with cancer by measuring the degree of fluorescence polarization using DPH as a fluorescent probe.The patients with coronary heart disease and the cancer patients were all of the TCM typology of blood stasis syndrome.The results showed:(1)The fluorescence polarization(P)of normal group was 0.294±0.007,and the microviscosity(π)was 3.656±0.237.(2)The P of the group of coronary heart disease with blood stasis syndrome was 0.328±0.013,and the π was 6.787±1.028. Both were signifi. cantly higher than those of the normal group(P<0.05),(3)The P of the group of cancer with blood stasis syndrome was 0.333±0.011,and the n was 6.698±1.357.Both were significanfly higher than those of the normal group(P<0.05).(4)Yet no significant difference was noticed between the group of coronary heart disease and the group of cancer(P>0.05). The higher then π erythrocyte membrane,the lower the fluidity of erythrocyte membrane.The lower fluidity of erythrocyte membrane in patients with blood stasis syndrome can result in the declined ability of erythrocytic deform which can accelerate the disturbance of microcirculation, This accords with the TCM theory about blood stasis syndrome.
出处
《中西医结合杂志》
CSCD
北大核心
1989年第7期405-406,388,共2页
