摘要
目的探讨转化生长因子β1(TGFβ1)和基质金属蛋白酶2,9(MMP2,9)在糖性白内障晶状体上皮细胞中的表达及意义。方法采用免疫组织化学技术检测TGFβ1及MMP2,9在糖性白内障(23例)和正常晶体状体(7例)上皮细胞中的表达。结果TGFβ1与MMP2,9在糖性白内障晶状体上皮中的阳性表达率显著高于正常晶状体(P<0.01),且TGFβ1与MMP2、MMP9均为正相关。结论TGFβ1介导的MMP2,9表达的失衡,对糖性白内障晶状体前后囊膜下的纤维化发生、发展起重要作用。
Objective To investigate the expression and significance of transforming growth factor-β1 （TGF-β1）, matrix metalloproteinase-2, 9 （MMP-2, 9） in human diabetic lens epithelial cells（LEC）. Methods Immunohistochemical staining was used to detect the expression of TGF-β1, MMP-2, 9 in the diabetic LEC （23 cases） and the normal LEC（7 cases）. Results There was significant difference of expression of TGF-β1 and MMP-2, 9 between diabetic LEC and normal LEC（P 〈 0.01）. There was correlation between the expression of TGF-β1 and MMP-2, TGF-β1 and MMP-9. Conclusion The expression of MMP-2, 9 indued by TGF-β1 may play a critical role in the pathological fibrosis of anterior and posterior subcapsula during the development of diabetic cataract.
出处
《福建医科大学学报》
2005年第3期288-290,共3页
Journal of Fujian Medical University
基金
福建省自然科学基金资助项目(C0510015)
关键词
白内障
金属蛋白酶类
转化生长因子Β
cataract
transforming growth factor beta
metalloproteases
