摘要
AIM： To investigate the level of nitric oxide （NO） and nitrous oxide synthase （NOS） enzyme and its effect on gastric mucosal pathologic change in patients infected with Helicobacter pylori （H pylori）, and to study the pathogenic mechanism of H pylori. METHODS： The mucosal tissues of gastric antrum were taken by endoscopy, then their pathology, H pylori and anti-CagA-IgG were determined. Fifty H pylori positive cases and 35 H pylori negative cases were randomly chosen. Serum level of NO and NOS was detected. RESULTS： One hundred and seven cases （71.33%） were anti-CagA-IgG positive in 150 H pyloripositive cases. The positive rate was higher especially in those with preneoplastic diseases, such as atrophy, intestinal metaplasia and dysplasia. The level of NO and NOS in positive group was higher than that in negative group, and apparently lower in active gastritis than in pre-neoplastic diseases such as atrophy, intestinal metaplasia and dysplasia. CONCLUSION： H pylori is closely related with chronic gastric diseases, and type I H pylori may be the real factor for H pylori-related gastric diseases. Infection with H pylori can induce elevation of NOS, which produces NO.
AIM: To investigate the level of nitric oxide (NO) and nitrous oxide synthase (NOS) enzyme and its effect on gastric mucosal pathologic change in patients infected with Helicobacter pylori (H pylori), and to study the pathogenic mechanism of H pylori.METHODS: The mucosal tissues of gastric antrum were taken by endoscopy, then their pathology, H pylori and anti-CagA-IgG were determined. Fifty H pyloripositive cases and 35 H pylori negative cases were randomly chosen.Serum level of NO and NOS was detected.RESULTS: One hundred and seven cases (71.33%) were anti-CagA-IgG positive in 150 H pyloripositive cases. The positive rate was higher especially in those with preneoplastic diseases, such as atrophy, intestinal metaplasia and dysplasia. The level of NO and NOS in positive group was higher than that in negative group, and apparently lower in active gastritis than in pre-neoplastic diseases such as atrophy, intestinal metaplasia and dysplasia.CONCLUSION: H pyloriis closely related with chronic gastric diseases, and type Ⅰ Hpylorimay be the real factor for Hpylori-related gastric diseases. Infection with H pylori can induce elevation of NOS, which produces NO.
基金
Supported by the Science and Technology Committee of Baotou,China, No. 2000-26
