摘要
目的探讨谷氨酰胺和生长激素对短肠综合征(SBS)患者的肠道代偿作用。方法26例短肠综合征患者残余小肠长度为0～100(中位数42.5)cm,手术后接受肠外营养(PN)支持3-52个月,联合应用生长激素(GH)(0.10±0.06)mg·kg-1·d-1和谷氨酰胺(GLN)(0.30±0.17)g·kg-1·d-1进行肠道促代偿治疗。结果26例接受GH加GLN治疗的SBS患者,其中9例(34.6%)治疗后近期内完全摆脱PN;8例(30.8%)经治疗后明显减少了PN用量,从每周需要PN(6.0±1.0)d下降至(4.2±1.0)d,每周PN需要量从(13.6±5.2)L降至(8.2±3.3)L;9例(34.6%)在治疗后仍依赖PN维持。结论经过合适的营养支持和肠道促代偿治疗,大多数短肠综合征患者残留肠道能充分代偿,完全摆脱PN或减少PN用量,长期健康生存。
Objective To assess the effects of parenteral glutamine and growth hormone supplementation on gut adaptation for patients with short bowel syndrome. Methods Twenty-six patients [male 15, female 11, aged （39 ± 23） years] with short bowel syndrome received parenteral nutrition （PN） 3 -52 months after surgical resection. The median length of remnant small intestine was 42.5 （0 - 100）cm. All patients received growth hormone （0. 10 ±0. 06）mg · kg^-1· d^-1 plus glutamine（0. 30 ±0. 17）mg · kg^-1 · d^-1 for two or three weeks. Results Among the 26 patients, PN was not required soon after treatment in 34. 6% （ n = 9） of the patients, the frequency and volume of PN decreased from（6. 0 ± 1.0）d to （4. 2 ± 1.0） d, from （ 13.6 ± 5.2） L per week to （8.2 ± 3.3 ） L per week respectively in 30. 8% （ n = 8） of the patients, while 34.6% （n = 9） still required PN after treatment. Conclusion The combined administration of glutamine and growth hormone can promote remnant intestinal adaptation in short bowel patients.
出处
《中华胃肠外科杂志》
CAS
2005年第5期429-431,共3页
Chinese Journal of Gastrointestinal Surgery
