1[1]Juliano R L, Ling V . A surface glycoprotein drug permeability in Chinese hamster ovary cell mutants. BBA: Biomembrans, 1976;455 ( 1 ): 152~162
2[2]Hipfner D R, Deeley R G, Cole S P C, et al .Structural mechanistic and clinical aspects of MRP1. BBA: Biomembrans, 1999; 1461 (2): 359~376
3[3]Fojo A T, Uede K, Slamon D J, et al. Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci USA, 1987;84(1) :265~269
4[4]Sugaware Isamu, Kataoka Iyo, Yasuyuk, et al. Tissue distribution of Pglycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK16. Cancer Res, 1988 ;48(7): 1926~1929
5[5]Rao V V, Dahlheimer J L, Bardgett M E, et al. Choroids plexus epithelial expression of MDR1 P-glycoprotein and multidrug resistance-related protein contributed to the blood-celebrospinal-fluid drug-permeability barrier. Proc Natl Acad Sci USA, 1999;96(7) :3900~3905
6[6]Sauna Z E and Ambudkar S V. Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-gp. Proc Natl Acad Sci USA, 2000;97(6):2515~2520
7[7]Ramachandra M, Ambudkar S V, Chen D, et al. Human p-glycoproein exhibits reduced affinity of substrates during a catalytic transiting state.Biochemistry, 1998; 37 (14): 5010~5019
8[8]Robinsin L J, Roberts W K, Ling T, et al. Human MDR1 protein overexpression relay the apoptotic cascade in Chinese hamster ovary fibroblast.Biochemistry, 1997;36(37): 11169~11178
9[9]Smyth M J, Krasovskis E, Sutton V R, et al. The drug effiux protein,P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis. Proc Natl Acad Sci USA, 1998; 95(12): 7024~ 7029
10[10]Cole S P C, Bhardwaj G, Gerlach J H, et al . Overexpression of a tesnaporter gene in a multidrug-resistance human lung cancer cell line. Science,1992; 258:1650~1654
二级参考文献36
1[1]Bush JA, Li G. Cancer chemoresistance: the relationship between P53 and Multidrug resistance [ J]. Int J Cancer,2002,98 ( 3 ) :323-330.
2[2]Dean M, Rzhetsky A, Allikmets R. The human ATP-binding cassette ( ABC ) transporter superfamily [J]. Genome Res,2001,11(7) :1156-1166.
3[3]Fojo AT, Ueda K, Slamon DJ, et al. Expression of a multidrugresistance gene in human tumors and tissues [ J ]. Proc Natl Acad Sci USA,1987,84( 1 ) :265-269.
4[4]Chin JE, Chen C J, Kriegler M,et al. Structure and expression of the human MDR (P-glycoprotein) gene family [ J ]. Mol Cell Biol, 1989,9(9) :3808-3820.
6[6]Schinkel AH, Wagenaar E , Mol CA, et al. P-glycoprotein in the blood brain barrier of mice influences the brain penetration and pharmacological activity of many drugs [ J]. J Clin Invest, 1996,97(11): 2517-2524.
7[7]Xie R, Hammarlund-Udenaes M, de Boer AG, et al. The role of P-glycoprotein in blood brain barrier transport of morphine:transcortical microdialysisstudies in Mdr1a ( / ) and Mdr1a (+/+) mice [J]. Br J Pharrnacol.1999,128(3) :563-568.
8[8]Rao VV, Dahlhejmer JL, Bardgett EM, et al. Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the bloodcerebrospinal-fluid drug-permeability barrier [ J ]. Proc Natl Acad Sci USA ,1999,96(7) :3900-3905.
9[9]Gottesman MM, Tito F, Bates SE. Multidrug resistance in cancer: role of ATP-dependent transportes [ J ]. Nature Cancer Rev,2002,2( 1 ) :49-58.
10[10]Paulusma CC,Piter J B, Guido JR,et al. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene [J]. Science,1996,271(5252): 1126-1128.