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TIMI研究——急性冠脉综合征的治疗前沿

TIMI Study——Advances in Treatment of Acute Coronary Syndrome
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摘要 TIMI是指心肌梗死中的溶栓治疗。TIMI研究致力于研究各种急性冠脉综合征中不同溶栓和抗栓治疗策略,其研究过程可分为三个阶段:经典的TIMI研究,重点观察不同溶栓剂的冠脉开通率及再灌注治疗方法;现代的TIMI研究,主要评价溶栓基础上抗栓治疗的作用及地位;未来的TIMI研究,旨在探讨综合治疗在急性冠脉综合征中的预后价值。TIMI研究始终站在急性冠脉综合征的治疗前沿,不断开发新药物,完善冠心病的治疗方案,彻底改变了传统的冠心病治疗观念。 TIMI （ Thrombolysis in Myocardial Infarction） studies focus on different thrombolytic and antithrombotic regimens for acute coronary syndrome and TIMI trials can be divided into three categories depending on use of the treatment regimens：TIMI classic,TIMI contemporary and TIMI future. TIMI classic puts emphasis on different thrombolytics and reperfusion strategies;TIMI contemporary mainly evaluates the function and position of anti-thrombin regimen based on thrombolysis;TIMI future points to prognosis value for integrated treatment in acute coronary syndrome.
作者 赵青 白小涓
机构地区 中国医科大学附属第一医院心内科
出处 《心血管病学进展》 CAS 2005年第5期457-460,共4页 Advances in Cardiovascular Diseases
关键词 TIMI 急性冠脉综合征 溶栓治疗 TIMI Acute coronary syndrome Thrombolysis
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献27

  • 1Rogers WJ,Baim DS,Gore JM,et al.Comparison of immediate invasive,delayed invasive,and conservative strategies after tissue-type plasminogen activator.Results of the Thrombolysis in Myocardial Infarction (TIMI) Phase II-A trial[J].Circulation,1990,81:1457-1476.
  • 2Williams DO,Braunwald E,Knatterud G,et al.One-year results of the Thrombolysis in Myocardial Infarction investigation (TIMI) Phase Ⅱ trial[J].Circulation,1992,85:533-542.
  • 3TIMI ⅢA Investigators.Early effects of tissue-type plasminogen activator added to conventional therapy on the culprit lesion in patients presenting with ischemic cardiac pain at rest.Results of the Thrombolysis in Myocardial Ischemia (TIMI ⅢA) Trial[J].Circulation,1993,87:38-52.
  • 4TIMI ⅢB Investigators.Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction:Results of the TIMI ⅢB Trial[J].Circulation,1994,89:1545-1556.
  • 5Cannon CP,McCabe CH,Diver DJ,et al.For the TIMI 4 Investigators.Comparison of front-loaded recombinant tissue-type plasminogen activator,anistreplase and combination thrombolytic therapy for acute myocardial infarction:results of the Thrombolysis in Myocardial Infarction (TIMI) 4 trial[J].J Am Coll Cardiol,1994,24:1602-1610.
  • 6Cannon CP,McCabe CH,Henry TD,et al.For the TIMI 5 Investigators.A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction:results of the Thrombolysis in Myocardial Infarction (TIMI) 5 trial[J].J Am Coll Cardiol,1994,23:993-1003.
  • 7Lee LV.For the TIMI 6 Investigators.Initial experience with hirudin and streptokinase in acute myocardial infarction:results of the Thrombolysis in Myocardial Infarction (TIMI) 6 trial[J].Am J Cardiol,1995,75:7-13.
  • 8Fuchs J,Cannon CP,TIMI 7 Investigators.Hirulog in the treatment of unstable angina.Results of the Thrombin Inhibition in Myocardial Ischemia (TIMI) 7 trial[J].Circulation,1995,92:727-733.
  • 9Antman EM,McCabe CH,Braunwald E.Bivalirudin as a replacement for unfractionated heparin in unstable angina/non-ST-elevation myocardial infarction:observations from the TIMI 8 trial.Thrombolysis in Myocardial Infarction[J].Am Heart J,2002,143:229-234.
  • 10Antman EM.For the TIMI 9A Investigators.Hirudin in acute myocardial infarction.Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial[J].Circulation,1994,90:1624-1630.
心血管病学进展
2005年 第5期

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